| Title |
The major inflammatory mediator interleukin-6 and obesity
|
|---|---|
| Published in |
Inflammation Research, June 2009
|
| DOI | 10.1007/s00011-009-0060-4 |
| Pubmed ID | |
| Authors |
Katalin Eder, Noemi Baffy, Andras Falus, Andras K. Fulop |
| Abstract |
Adipose tissue is one of the main sources of inflammatory mediators, with interleukin-6 (IL-6) among them. Although high systemic levels of inflammatory mediators are cachectogenic and/or anorexic, today it is a widely propagated thesis that in the background of obesity, a low level of chronic inflammation can be found, with IL-6 being one of the many suggested mediators. This paper reviews the studies describing elevated IL-6 levels in obese patients and the role of adipocytes and adipose-tissue macrophages in the production of IL-6. The secretion of IL-6 is regulated by several physiologic or pathologic factors: hormones, cytokines, diet, physical activity, stress, hypoxia, and others. Adipose tissue-derived IL-6 may have an effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Having a better understanding of these mechanisms may contribute to the prevention and treatment of obesity. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 413 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Canada | 2 | <1% |
| United Kingdom | 2 | <1% |
| Colombia | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| New Zealand | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 402 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 18% |
| Student > Master | 59 | 14% |
| Student > Bachelor | 49 | 12% |
| Researcher | 44 | 11% |
| Student > Doctoral Student | 31 | 8% |
| Other | 77 | 19% |
| Unknown | 80 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 103 | 25% |
| Agricultural and Biological Sciences | 74 | 18% |
| Biochemistry, Genetics and Molecular Biology | 58 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 4% |
| Sports and Recreations | 11 | 3% |
| Other | 51 | 12% |
| Unknown | 101 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2021.
All research outputs
#7,488,463
of 24,144,324 outputs
Outputs from Inflammation Research
#241
of 1,003 outputs
Outputs of similar age
#37,331
of 114,535 outputs
Outputs of similar age from Inflammation Research
#7
of 9 outputs
Altmetric has tracked 24,144,324 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,003 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,535 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.