| Title |
Bitter Melon Enhances Natural Killer–Mediated Toxicity against Head and Neck Cancer Cells
|
|---|---|
| Published in |
Cancer Prevention Research, June 2017
|
| DOI | 10.1158/1940-6207.capr-17-0046 |
| Pubmed ID | |
| Authors |
Sourav Bhattacharya, Naoshad Muhammad, Robert Steele, Jacki Kornbluth, Ratna B. Ray |
| Abstract |
Natural Killer (NK) cells are one of the major components of innate immunity, with the ability to mediate antitumor activity. Understanding the role of NK cell mediated tumor killing in controling of solid tumor growth is still in the developmental stage. We have shown recently that bitter melon extract (BME) modulates the regulatory T cell (Treg) population in head and neck squamous cell carcinoma (HNSCC). However, the role of BME in NK cell modulation against HNSCC remains unknown. In this study, we investigated whether BME can enhance the NK cell killing activity against HNSCC cells. Our results indicated that treatment of human NK cell line (NK3.3) with BME enhances ability to kill HNSCC cells. BME increases granzyme B accumulation and translocation/accumulation of CD107a/LAMP1 in NK3.3 cells exposed to BME. Further, an increase in cell surface expression of CD16 and NKp30 in BME treated NK3.3 cells was observed when co-cultured with HNSCC cells. Collectively, our results demonstrated for the first time that BME augments NK cell mediated HNSCC killing activity, implicating an immunomodulatory role of BME. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 16% |
| Student > Bachelor | 2 | 6% |
| Student > Postgraduate | 2 | 6% |
| Student > Ph. D. Student | 1 | 3% |
| Other | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 19 | 59% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 25% |
| Computer Science | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Immunology and Microbiology | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 16 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2023.
All research outputs
#8,346,834
of 25,775,807 outputs
Outputs from Cancer Prevention Research
#674
of 1,461 outputs
Outputs of similar age
#122,625
of 331,596 outputs
Outputs of similar age from Cancer Prevention Research
#5
of 11 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,461 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.6. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,596 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.