| Title |
Beneficial neurocognitive effects of transcranial laser in older adults
|
|---|---|
| Published in |
Lasers in Medical Science, May 2017
|
| DOI | 10.1007/s10103-017-2221-y |
| Pubmed ID | |
| Authors |
Enrique Vargas, Douglas W. Barrett, Celeste L. Saucedo, Li-Da Huang, Jacob A. Abraham, Hirofumi Tanaka, Andreana P. Haley, F. Gonzalez-Lima |
| Abstract |
Transcranial infrared laser stimulation (TILS) at 1064 nm, 250 mW/cm(2) has been proven safe and effective for increasing neurocognitive functions in young adults in controlled studies using photobiomodulation of the right prefrontal cortex. The objective of this pilot study was to determine whether there is any effect from TILS on neurocognitive function in older adults with subjective memory complaint at risk for cognitive decline (e.g., increased carotid artery intima-media thickness or mild traumatic brain injury). We investigated the cognitive effects of TILS in older adults (ages 49-90, n = 12) using prefrontal cortex measures of attention (psychomotor vigilance task (PVT)) and memory (delayed match to sample (DMS)), carotid artery intima-media thickness (measured by ultrasound), and evaluated the potential neural mechanisms mediating the cognitive effects of TILS using exploratory brain studies of electroencephalography (EEG, n = 6) and functional magnetic resonance imaging (fMRI, n = 6). Cognitive performance, age, and carotid artery intima-media thickness were highly correlated, but all participants improved in all cognitive measures after TILS treatments. Baseline vs. chronic (five weekly sessions, 8 min each) comparisons of mean cognitive scores all showed improvements, significant for PVT reaction time (p < 0.001), PVT lapses (p < 0.001), and DMS correct responses (p < 0.05). The neural studies also showed for the first time that TILS increases resting-state EEG alpha, beta, and gamma power and promotes more efficient prefrontal blood-oxygen-level-dependent (BOLD)-fMRI response. Importantly, no adverse effects were found. These preliminary findings support the use of TILS for larger randomized clinical trials with this non-invasive approach to augment neurocognitive function in older people to combat aging-related and vascular disease-related cognitive decline. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 23% |
| Spain | 1 | 8% |
| Australia | 1 | 8% |
| Canada | 1 | 8% |
| United States | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Practitioners (doctors, other healthcare professionals) | 2 | 15% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 201 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 14% |
| Student > Ph. D. Student | 22 | 11% |
| Student > Bachelor | 22 | 11% |
| Researcher | 20 | 10% |
| Student > Doctoral Student | 15 | 7% |
| Other | 35 | 17% |
| Unknown | 59 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 14% |
| Neuroscience | 27 | 13% |
| Psychology | 25 | 12% |
| Nursing and Health Professions | 13 | 6% |
| Engineering | 8 | 4% |
| Other | 32 | 16% |
| Unknown | 67 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#1,126,212
of 25,373,627 outputs
Outputs from Lasers in Medical Science
#14
of 1,406 outputs
Outputs of similar age
#22,336
of 324,892 outputs
Outputs of similar age from Lasers in Medical Science
#2
of 31 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,406 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.