Title |
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well‐being: The growing up in Singapore toward healthy outcomes cohort
|
---|---|
Published in |
Depression & Anxiety (1091-4269), May 2017
|
DOI | 10.1002/da.22637 |
Pubmed ID | |
Authors |
Linde van Lee, Phaik Ling Quah, Seang Mei Saw, Fabian K. P. Yap, Keith M. Godfrey, Yap Seng Chong, Michael J Meaney, Helen Chen, Mary Foong‐Fong Chong |
Abstract |
Choline and betaine status have previously been associated with symptoms of depression. However, the relation of maternal plasma choline and betaine concentrations in pregnancy to peripartum maternal mood is unknown. Maternal plasma choline and betaine concentrations (μmol/L) were measured at 26-28 weeks gestation in the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. Participants completed the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EDPS) at 26-28 weeks gestation (n = 949) and at 3 months postnatal (n = 689): higher scores are indicative of more symptoms of anxiety and depression. Multivariate linear regression models were used to estimate the association of choline and betaine with ante- and postnatal mental well-being adjusting for covariates. Mean (SD) antenatal plasma choline and betaine concentrations were 9.2 μmol/L (1.6) and 13.1 μmol/L (2.7), respectively. Plasma choline concentrations were positively associated with antenatal depressive (β = .24 EPDS score [95% CI: 0.05-0.43] per μmol/L] and anxiety symptoms (β = .46 STAI-state score [95% CI: 0.03-0.88] per μmol/L) adjusting for covariates. Plasma betaine concentrations were not associated with antenatal depression or anxiety symptoms. No associations were observed between pregnancy choline or betaine and postnatal mental well-being. This study suggests that higher maternal plasma choline status during pregnancy is associated with more symptoms of antenatal depression and anxiety, whereas plasma betaine concentrations showed no associations. No associations were observed for postnatal mental well-being. Prospective studies are required to replicate these findings and further examine the direction of causality and possible biological mechanisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 13% |
Student > Master | 9 | 13% |
Student > Bachelor | 7 | 10% |
Student > Ph. D. Student | 6 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 14 | 19% |
Unknown | 23 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 17% |
Psychology | 12 | 17% |
Nursing and Health Professions | 9 | 13% |
Social Sciences | 6 | 8% |
Neuroscience | 3 | 4% |
Other | 6 | 8% |
Unknown | 24 | 33% |