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Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well‐being: The growing up in Singapore toward healthy outcomes cohort

Overview of attention for article published in Depression & Anxiety (1091-4269), May 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)

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Title
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well‐being: The growing up in Singapore toward healthy outcomes cohort
Published in
Depression & Anxiety (1091-4269), May 2017
DOI 10.1002/da.22637
Pubmed ID
Authors

Linde van Lee, Phaik Ling Quah, Seang Mei Saw, Fabian K. P. Yap, Keith M. Godfrey, Yap Seng Chong, Michael J Meaney, Helen Chen, Mary Foong‐Fong Chong

Abstract

Choline and betaine status have previously been associated with symptoms of depression. However, the relation of maternal plasma choline and betaine concentrations in pregnancy to peripartum maternal mood is unknown. Maternal plasma choline and betaine concentrations (μmol/L) were measured at 26-28 weeks gestation in the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. Participants completed the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EDPS) at 26-28 weeks gestation (n = 949) and at 3 months postnatal (n = 689): higher scores are indicative of more symptoms of anxiety and depression. Multivariate linear regression models were used to estimate the association of choline and betaine with ante- and postnatal mental well-being adjusting for covariates. Mean (SD) antenatal plasma choline and betaine concentrations were 9.2 μmol/L (1.6) and 13.1 μmol/L (2.7), respectively. Plasma choline concentrations were positively associated with antenatal depressive (β = .24 EPDS score [95% CI: 0.05-0.43] per μmol/L] and anxiety symptoms (β = .46 STAI-state score [95% CI: 0.03-0.88] per μmol/L) adjusting for covariates. Plasma betaine concentrations were not associated with antenatal depression or anxiety symptoms. No associations were observed between pregnancy choline or betaine and postnatal mental well-being. This study suggests that higher maternal plasma choline status during pregnancy is associated with more symptoms of antenatal depression and anxiety, whereas plasma betaine concentrations showed no associations. No associations were observed for postnatal mental well-being. Prospective studies are required to replicate these findings and further examine the direction of causality and possible biological mechanisms.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 13%
Student > Master 9 13%
Student > Bachelor 7 10%
Student > Ph. D. Student 6 8%
Student > Doctoral Student 4 6%
Other 14 19%
Unknown 23 32%
Readers by discipline Count As %
Medicine and Dentistry 12 17%
Psychology 12 17%
Nursing and Health Professions 9 13%
Social Sciences 6 8%
Neuroscience 3 4%
Other 6 8%
Unknown 24 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2017.
All research outputs
#4,572,964
of 25,477,125 outputs
Outputs from Depression & Anxiety (1091-4269)
#653
of 1,714 outputs
Outputs of similar age
#73,517
of 324,612 outputs
Outputs of similar age from Depression & Anxiety (1091-4269)
#33
of 43 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.5. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.