| Title |
IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice
|
|---|---|
| Published in |
Molecular Neurobiology, December 2013
|
| DOI | 10.1007/s12035-013-8585-5 |
| Pubmed ID | |
| Authors |
Carla Lopes, Márcio Ribeiro, Ana I. Duarte, Sandrine Humbert, Frederic Saudou, Luís Pereira de Almeida, Michael Hayden, A. Cristina Rego |
| Abstract |
Huntington's disease (HD) is an autosomal dominant disease caused by an expansion of CAG repeats in the gene encoding for huntingtin. Brain metabolic dysfunction and altered Akt signaling pathways have been associated with disease progression. Nevertheless, conflicting results persist regarding the role of insulin-like growth factor-1 (IGF-1)/Akt pathway in HD. While high plasma levels of IGF-1 correlated with cognitive decline in HD patients, other data showed protective effects of IGF-1 in HD striatal neurons and R6/2 mice. Thus, in the present study, we investigated motor phenotype, peripheral and central metabolic profile, and striatal and cortical signaling pathways in YAC128 mice subjected to intranasal administration of recombinant human IGF-1 (rhIGF-1) for 2 weeks, in order to promote IGF-1 delivery to the brain. We show that IGF-1 supplementation enhances IGF-1 cortical levels and improves motor activity and both peripheral and central metabolic abnormalities in YAC128 mice. Moreover, decreased Akt activation in HD mice brain was ameliorated following IGF-1 administration. Upregulation of Akt following rhIGF-1 treatment occurred concomitantly with increased phosphorylation of mutant huntingtin on Ser421. These data suggest that intranasal administration of rhIGF-1 ameliorates HD-associated glucose metabolic brain abnormalities and mice phenotype. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 1% |
| United States | 1 | 1% |
| Italy | 1 | 1% |
| Austria | 1 | 1% |
| Unknown | 73 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 26% |
| Student > Master | 9 | 12% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 7 | 9% |
| Other | 10 | 13% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 25% |
| Agricultural and Biological Sciences | 16 | 21% |
| Medicine and Dentistry | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Engineering | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 19 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#18,357,514
of 22,736,112 outputs
Outputs from Molecular Neurobiology
#2,449
of 3,434 outputs
Outputs of similar age
#230,575
of 305,967 outputs
Outputs of similar age from Molecular Neurobiology
#15
of 27 outputs
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