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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

Overview of attention for article published in Nature, December 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Citations

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1625 Dimensions

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1442 Mendeley
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6 CiteULike
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Title
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Published in
Nature, December 2013
DOI 10.1038/nature12876
Pubmed ID
Authors

Frédéric Ariey, Benoit Witkowski, Chanaki Amaratunga, Johann Beghain, Anne-Claire Langlois, Nimol Khim, Saorin Kim, Valentine Duru, Christiane Bouchier, Laurence Ma, Pharath Lim, Rithea Leang, Socheat Duong, Sokunthea Sreng, Seila Suon, Char Meng Chuor, Denis Mey Bout, Sandie Ménard, William O. Rogers, Blaise Genton, Thierry Fandeur, Olivo Miotto, Pascal Ringwald, Jacques Le Bras, Antoine Berry, Jean-Christophe Barale, Rick M. Fairhurst, Françoise Benoit-Vical, Odile Mercereau-Puijalon, Didier Ménard

Abstract

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,442 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 8 <1%
United States 7 <1%
France 5 <1%
Brazil 3 <1%
Switzerland 2 <1%
Ghana 2 <1%
Kenya 2 <1%
Pakistan 1 <1%
Norway 1 <1%
Other 17 1%
Unknown 1394 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 297 21%
Student > Master 219 15%
Researcher 204 14%
Student > Bachelor 169 12%
Student > Doctoral Student 73 5%
Other 204 14%
Unknown 276 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 358 25%
Biochemistry, Genetics and Molecular Biology 289 20%
Medicine and Dentistry 144 10%
Chemistry 69 5%
Immunology and Microbiology 69 5%
Other 196 14%
Unknown 317 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 169. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2023.
All research outputs
#224,514
of 24,384,776 outputs
Outputs from Nature
#13,241
of 94,898 outputs
Outputs of similar age
#2,056
of 316,416 outputs
Outputs of similar age from Nature
#181
of 930 outputs
Altmetric has tracked 24,384,776 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 94,898 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 101.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,416 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 930 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.