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Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome

Overview of attention for article published in JAMA Pediatrics, July 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
34 news outlets
blogs
6 blogs
policy
1 policy source
twitter
245 X users
patent
2 patents
facebook
81 Facebook pages
googleplus
4 Google+ users
reddit
2 Redditors
video
1 YouTube creator

Citations

dimensions_citation
721 Dimensions

Readers on

mendeley
1111 Mendeley
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Title
Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome
Published in
JAMA Pediatrics, July 2017
DOI 10.1001/jamapediatrics.2017.0378
Pubmed ID
Authors

Pia S. Pannaraj, Fan Li, Chiara Cerini, Jeffrey M. Bender, Shangxin Yang, Adrienne Rollie, Helty Adisetiyo, Sara Zabih, Pamela J. Lincez, Kyle Bittinger, Aubrey Bailey, Frederic D. Bushman, John W. Sleasman, Grace M. Aldrovandi

Abstract

Establishment of the infant microbiome has lifelong implications on health and immunity. Gut microbiota of breastfed compared with nonbreastfed individuals differ during infancy as well as into adulthood. Breast milk contains a diverse population of bacteria, but little is known about the vertical transfer of bacteria from mother to infant by breastfeeding. To determine the association between the maternal breast milk and areolar skin and infant gut bacterial communities. In a prospective, longitudinal study, bacterial composition was identified with sequencing of the 16S ribosomal RNA gene in breast milk, areolar skin, and infant stool samples of 107 healthy mother-infant pairs. The study was conducted in Los Angeles, California, and St Petersburg, Florida, between January 1, 2010, and February 28, 2015. Amount and duration of daily breastfeeding and timing of solid food introduction. Bacterial composition in maternal breast milk, areolar skin, and infant stool by sequencing of the 16S ribosomal RNA gene. In the 107 healthy mother and infant pairs (median age at the time of specimen collection, 40 days; range, 1-331 days), 52 (43.0%) of the infants were male. Bacterial communities were distinct in milk, areolar skin, and stool, differing in both composition and diversity. The infant gut microbial communities were more closely related to an infant's mother's milk and skin compared with a random mother (mean difference in Bray-Curtis distances, 0.012 and 0.014, respectively; P < .001 for both). Source tracking analysis was used to estimate the contribution of the breast milk and areolar skin microbiomes to the infant gut microbiome. During the first 30 days of life, infants who breastfed to obtain 75% or more of their daily milk intake received a mean (SD) of 27.7% (15.2%) of the bacteria from breast milk and 10.3% (6.0%) from areolar skin. Bacterial diversity (Faith phylogenetic diversity, P = .003) and composition changes were associated with the proportion of daily breast milk intake in a dose-dependent manner, even after the introduction of solid foods. The results of this study indicate that bacteria in mother's breast milk seed the infant gut, underscoring the importance of breastfeeding in the development of the infant gut microbiome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 245 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
United States 1 <1%
Unknown 1107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 152 14%
Student > Master 148 13%
Student > Bachelor 135 12%
Researcher 126 11%
Student > Doctoral Student 54 5%
Other 163 15%
Unknown 333 30%
Readers by discipline Count As %
Medicine and Dentistry 194 17%
Biochemistry, Genetics and Molecular Biology 122 11%
Agricultural and Biological Sciences 120 11%
Immunology and Microbiology 101 9%
Nursing and Health Professions 88 8%
Other 105 9%
Unknown 381 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 472. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2024.
All research outputs
#57,190
of 25,452,734 outputs
Outputs from JAMA Pediatrics
#231
of 6,713 outputs
Outputs of similar age
#1,221
of 327,022 outputs
Outputs of similar age from JAMA Pediatrics
#7
of 82 outputs
Altmetric has tracked 25,452,734 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,713 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 79.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,022 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.