| Title |
Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
|
|---|---|
| Published in |
Quality of Life Research, March 2017
|
| DOI | 10.1007/s11136-017-1539-z |
| Pubmed ID | |
| Authors |
Eline H. van Roekel, Martijn J. L. Bours, Malou E. M. te Molder, José J. L. Breedveld-Peters, Steven W. M. Olde Damink, Leo J. Schouten, Silvia Sanduleanu, Geerard L. Beets, Matty P. Weijenberg |
| Abstract |
Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2-10 years post-diagnosis. A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002-2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm(2)); intermuscular adipose tissue area (cm(2)) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm(2)/m(2)) as measure of muscle mass and for determining sarcopenia. Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm(2) (standard deviation: 93.4) and SMI of 47.8 cm(2)/m(2) (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences. Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I-III CRC survivors. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Australia | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 15% |
| Student > Ph. D. Student | 15 | 13% |
| Student > Bachelor | 10 | 9% |
| Student > Postgraduate | 8 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 19 | 17% |
| Unknown | 37 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 33% |
| Nursing and Health Professions | 13 | 12% |
| Psychology | 6 | 5% |
| Sports and Recreations | 4 | 4% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 9 | 8% |
| Unknown | 41 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2017.
All research outputs
#13,316,630
of 22,971,207 outputs
Outputs from Quality of Life Research
#1,352
of 2,910 outputs
Outputs of similar age
#167,613
of 333,986 outputs
Outputs of similar age from Quality of Life Research
#31
of 86 outputs
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