| Title |
T regulatory cells and Th1/Th2 cytokines in peripheral blood from tuberculosis patients
|
|---|---|
| Published in |
European Journal of Clinical Microbiology & Infectious Diseases, March 2010
|
| DOI | 10.1007/s10096-010-0908-0 |
| Pubmed ID | |
| Authors |
X.-Y. He, L. Xiao, H.-B. Chen, J. Hao, J. Li, Y.-J. Wang, K. He, Y. Gao, B.-Y. Shi |
| Abstract |
About 10% of people infected with Mycobacterium tuberculosis develop active tuberculosis (TB), and Th1 effector cells and Th1 cytokines play key roles in controlling M. tuberculosis infection. Here, we hypothesise that this susceptibility to M. tuberculosis infection is linked to increased T regulatory (Treg) cells and Th2 cytokines in TB patients. To test this, we recruited 101 participants (71 TB patients, 12 non-TB pulmonary diseases and 18 healthy subjects) and investigated Treg cells and Th1/Th2 cytokines in peripheral blood. CD4(+)CD25(+) T cells and CD4(+)CD25(+)FoxP3(+) T cells significantly increased and IL-5 dramatically decreased in TB patients relative to healthy subjects. CD8(+)CD28(-) T cells, IFN-gamma, TNF-alpha, IL-10 and IL-4 significantly increased in patients with culture and sputum smear-positive pulmonary TB (PTB(+)) compared with healthy subjects. CD4(+)CD25(+)FoxP3(+) and CD8(+)CD28(-) T cells significantly decreased in PTB(+) after one month of chemotherapy. CD4(+), CD4(+)CD25(+) and CD8(+)CD28(+) T cells significantly increased in extra-pulmonary TB patients after one month of chemotherapy. These findings suggest that M. tuberculosis infection induces circulating CD4(+)CD25(+)FoxP3(+) and CD8(+)CD28(-) T cell expansion, which may be related to the progression of M. tuberculosis infection, and that the balance between effector immune responses and suppression immune responses is essential to control M. tuberculosis infection. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 21% |
| Researcher | 12 | 19% |
| Student > Master | 9 | 14% |
| Student > Doctoral Student | 8 | 13% |
| Student > Postgraduate | 6 | 10% |
| Other | 11 | 17% |
| Unknown | 4 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 30% |
| Agricultural and Biological Sciences | 17 | 27% |
| Immunology and Microbiology | 13 | 21% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Computer Science | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 6 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2013.
All research outputs
#18,357,514
of 22,736,112 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#2,160
of 2,769 outputs
Outputs of similar age
#85,230
of 94,429 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#8
of 12 outputs
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