| Title |
Lung Organoids and Their Use To Study Cell-Cell Interaction
|
|---|---|
| Published in |
Current Pathobiology Reports, April 2017
|
| DOI | 10.1007/s40139-017-0137-7 |
| Pubmed ID | |
| Authors |
Marko Z. Nikolić, Emma L. Rawlins |
| Abstract |
The lung research field has pioneered the use of organoids for the study of cell-cell interactions. The use of organoids for airway basal cells is routine. However, the development of organoids for the other regions of the lung is still in its infancy. Such cultures usually rely on cell-cell interactions between the stem cells and a putative niche cell for their growth and differentiation. The use of co-culture organoid systems has facilitated the in vitro cultivation of previously inaccessible stem cell populations, providing a novel method for dissecting the molecular requirements of these cell-cell interactions. Future technology development will allow the growth of epithelial-only organoids in more defined media and also the introduction of specific non-epithelial cells for the study of cell interactions. These developments will require an improved understanding of the epithelial and non-epithelial cell types present in the lung and their lineage relationships. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| China | 1 | 10% |
| Australia | 1 | 10% |
| United States | 1 | 10% |
| Germany | 1 | 10% |
| India | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 3 | 30% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 170 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 19% |
| Researcher | 29 | 17% |
| Student > Bachelor | 20 | 12% |
| Student > Master | 17 | 10% |
| Other | 9 | 5% |
| Other | 27 | 16% |
| Unknown | 37 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 30% |
| Agricultural and Biological Sciences | 23 | 13% |
| Immunology and Microbiology | 14 | 8% |
| Medicine and Dentistry | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 18 | 11% |
| Unknown | 45 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
All research outputs
#5,728,223
of 23,301,510 outputs
Outputs from Current Pathobiology Reports
#22
of 105 outputs
Outputs of similar age
#88,949
of 310,525 outputs
Outputs of similar age from Current Pathobiology Reports
#4
of 8 outputs
Altmetric has tracked 23,301,510 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 105 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.