| Title |
Roles and functions of HIV-1 Tat protein in the CNS: an overview
|
|---|---|
| Published in |
Virology Journal, December 2013
|
| DOI | 10.1186/1743-422x-10-358 |
| Pubmed ID | |
| Authors |
Asen Bagashev, Bassel E Sawaya |
| Abstract |
Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated neurocognitive disorders (HAND). HIV-1 Tat (a key HIV transactivator of transcription) protein is one of the first HIV proteins to be expressed after infection occurs and is absolutely required for the initiation of the HIV genome transcription. In addition to its canonical functions, various studies have shown the deleterious role of HIV-1 Tat in the development and progression of HAND. Within the CNS, only specific cell types can support productive viral replication (astrocytes and microglia), however Tat protein can be released form infected cells to affects HIV non-permissive cells such as neurons. Therefore, in this review, we will summarize the functions of HIV-1 Tat proteins in neural cells and its ability to promote HAND. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 145 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Student > Bachelor | 24 | 16% |
| Student > Master | 23 | 15% |
| Researcher | 16 | 11% |
| Student > Doctoral Student | 12 | 8% |
| Other | 19 | 13% |
| Unknown | 19 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 19% |
| Agricultural and Biological Sciences | 27 | 18% |
| Medicine and Dentistry | 19 | 13% |
| Immunology and Microbiology | 15 | 10% |
| Neuroscience | 9 | 6% |
| Other | 26 | 17% |
| Unknown | 25 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2015.
All research outputs
#3,263,414
of 22,738,543 outputs
Outputs from Virology Journal
#315
of 3,035 outputs
Outputs of similar age
#40,147
of 306,115 outputs
Outputs of similar age from Virology Journal
#8
of 55 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,115 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.