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Mendeley readers
Attention Score in Context
| Title |
Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells
|
|---|---|
| Published in |
PLoS Neglected Tropical Diseases, March 2013
|
| DOI | 10.1371/journal.pntd.0002124 |
| Pubmed ID | |
| Authors |
Stefan W. Metz, Joy Gardner, Corinne Geertsema, Thuy T. Le, Lucas Goh, Just M. Vlak, Andreas Suhrbier, Gorben P. Pijlman |
| Abstract |
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is rapidly scalable to volumes required for epidemic responses and proved well suited for processing of CHIKV glycoproteins and production of enveloped VLPs. Herein we show that a single immunization with 1 µg of non-adjuvanted CHIKV VLPs induced high titer neutralizing antibody responses and provided complete protection against viraemia and joint inflammation upon challenge with the Réunion Island CHIKV strain in an adult wild-type mouse model of CHIKV disease. CHIKV VLPs produced in insect cells using recombinant baculoviruses thus represents as a new, safe, non-replicating and effective vaccine candidate against CHIKV infections. |
Mendeley readers
The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 197 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 16% |
| Student > Ph. D. Student | 31 | 15% |
| Student > Bachelor | 30 | 15% |
| Student > Master | 27 | 13% |
| Other | 14 | 7% |
| Other | 38 | 19% |
| Unknown | 30 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 29% |
| Biochemistry, Genetics and Molecular Biology | 47 | 23% |
| Immunology and Microbiology | 15 | 7% |
| Medicine and Dentistry | 11 | 5% |
| Veterinary Science and Veterinary Medicine | 4 | 2% |
| Other | 27 | 13% |
| Unknown | 40 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2022.
All research outputs
#3,138,740
of 25,374,917 outputs
Outputs from PLoS Neglected Tropical Diseases
#2,140
of 9,377 outputs
Outputs of similar age
#25,453
of 209,244 outputs
Outputs of similar age from PLoS Neglected Tropical Diseases
#31
of 153 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,377 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,244 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.