Title |
Altered sputum granzyme B and granzyme B/proteinase inhibitor‐9 in patients with non‐eosinophilic asthma
|
---|---|
Published in |
Respirology, December 2013
|
DOI | 10.1111/resp.12213 |
Pubmed ID | |
Authors |
Jodie L Simpson, Peter G Gibson, Ian A Yang, John Upham, Alan James, Paul N Reynolds, Sandra Hodge |
Abstract |
The non-eosinophilic phenotype of asthma (NEA) is associated with chronic airway inflammation and airway neutrophilia. An accumulation of apoptotic airway epithelial cells, if not efficiently cleared by efferocytosis, can undergo secondary necrosis, with the potential for inflammation of surrounding tissues. Apoptosis may occur via the T cell granzyme B pathway. The role of granzyme B in NEA is not known. The aim of this study was to investigate production of granzyme B and its inhibitor proteinase inhibitor (PI)-9 by T cells from induced sputum and compare expression between eosinophilic, NEA and healthy controls. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 20% |
Argentina | 1 | 10% |
Australia | 1 | 10% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 60% |
Scientists | 2 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Student > Bachelor | 1 | 9% |
Lecturer | 1 | 9% |
Professor | 1 | 9% |
Other | 3 | 27% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 36% |
Agricultural and Biological Sciences | 4 | 36% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Unknown | 2 | 18% |