| Title |
The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP
|
|---|---|
| Published in |
BMC Veterinary Research, December 2013
|
| DOI | 10.1186/1746-6148-9-259 |
| Pubmed ID | |
| Authors |
Cyrina D van Beusekom, Jeroen JMW van den Heuvel, Jan B Koenderink, Johannes A Schrickx, Frans GM Russel |
| Abstract |
The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver diseases has not been studied in detail, but the same mechanism of inhibition by drugs as in humans could play a role in veterinary medicine. The aim of this study was to investigate the functional characteristics of feline Bsep in comparison with canine and human Bsep/BSEP with respect to substrate affinities and inhibitory potential of model drugs. Orthologs of all three species were cloned and cell membrane vesicles overexpressing feline, canine and human Bsep/BSEP were prepared for functional analyses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 22% |
| Student > Master | 4 | 17% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Doctoral Student | 1 | 4% |
| Professor | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 6 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 22% |
| Agricultural and Biological Sciences | 3 | 13% |
| Medicine and Dentistry | 2 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Unspecified | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 7 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2013.
All research outputs
#20,215,721
of 22,738,543 outputs
Outputs from BMC Veterinary Research
#2,411
of 3,037 outputs
Outputs of similar age
#265,934
of 306,076 outputs
Outputs of similar age from BMC Veterinary Research
#51
of 58 outputs
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