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Mendeley readers
Attention Score in Context
| Title |
Human CD8+ CD57- TEMRA cells: Too young to be called "old"
|
|---|---|
| Published in |
PLOS ONE, May 2017
|
| DOI | 10.1371/journal.pone.0177405 |
| Pubmed ID | |
| Authors |
Kriti Verma, Justyna Ogonek, Pavankumar Reddy Varanasi, Susanne Luther, Ivonne Bünting, Katrin Thomay, Yvonne Lisa Behrens, Eva Mischak-Weissinger, Lothar Hambach |
| Abstract |
End-stage differentiation of antigen-specific T-cells may precede loss of immune responses against e.g. viral infections after allogeneic stem cell transplantation (SCT). Antigen-specific CD8+ T-cells detected by HLA/peptide multimers largely comprise CD45RA-/CCR7- effector memory (TEM) and CD45RA+/CCR7- TEMRA subsets. A majority of terminally differentiated T-cells is considered to be part of the heterogeneous TEMRA subset. The senescence marker CD57 has been functionally described in memory T-cells mainly composed of central memory (TCM) and TEM cells. However, its role specifically in TEMRA cells remained undefined. Here, we investigated the relevance of CD57 to separate human CD8+ TEMRA cells into functionally distinct subsets. CD57- CD8+ TEMRA cells isolated from healthy donors had considerably longer telomeres and showed significantly more BrdU uptake and IFN-γ release upon stimulation compared to the CD57+ counterpart. Cytomegalovirus (CMV) specific T-cells isolated from patients after allogeneic SCT were purified into CD57+ and CD57- TEMRA subsets. CMV specific CD57- TEMRA cells had longer telomeres and a considerably higher CMV peptide sensitivity in BrdU uptake and IFN-γ release assays compared to CD57+ TEMRA cells. In contrast, CD57+ and CD57- TEMRA cells showed comparable peptide specific cytotoxicity. Finally, CD57- CD8+ TEMRA cells partially changed phenotypically into TEM cells and gained CD57 expression, while CD57+ CD8+ TEMRA cells hardly changed phenotypically and showed considerable cell death after in vitro stimulation. To the best of our knowledge, these data show for the first time that CD57 separates CD8+ TEMRA cells into a terminally differentiated CD57+ population and a so far functionally undescribed "young" CD57- TEMRA subset with high proliferative capacity and differentiation plasticity. |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 23% |
| Researcher | 28 | 19% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 14 | 9% |
| Student > Doctoral Student | 11 | 7% |
| Other | 13 | 9% |
| Unknown | 36 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 53 | 35% |
| Biochemistry, Genetics and Molecular Biology | 19 | 13% |
| Medicine and Dentistry | 19 | 13% |
| Agricultural and Biological Sciences | 9 | 6% |
| Neuroscience | 3 | 2% |
| Other | 10 | 7% |
| Unknown | 38 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2023.
All research outputs
#7,583,588
of 23,770,218 outputs
Outputs from PLOS ONE
#93,359
of 202,869 outputs
Outputs of similar age
#116,416
of 311,936 outputs
Outputs of similar age from PLOS ONE
#1,696
of 4,379 outputs
Altmetric has tracked 23,770,218 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 202,869 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,936 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 4,379 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.