Title |
Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
|
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Published in |
Genome Biology, December 2013
|
DOI | 10.1186/gb-2013-14-12-r144 |
Pubmed ID | |
Authors |
Gabriel G Malouf, Joseph H Taube, Yue Lu, Tapasree Roysarkar, Shoghag Panjarian, Marcos RH Estecio, Jaroslav Jelinek, Jumpei Yamazaki, Noel J-M Raynal, Hai Long, Tomomitsu Tahara, Agata Tinnirello, Priyanka Ramachandran, Xiu-Ying Zhang, Shoudan Liang, Sendurai A Mani, Jean-Pierre J Issa |
Abstract |
Epithelial-mesenchymal transition (EMT) is known to impart metastasis and stemness characteristics in breast cancer. To characterize the epigenetic reprogramming following Twist1-induced EMT, we characterized the epigenetic and transcriptome landscapes using whole-genome transcriptome analysis by RNA-seq, DNA methylation by digital restriction enzyme analysis of methylation (DREAM) and histone modifications by CHIP-seq of H3K4me3 and H3K27me3 in immortalized human mammary epithelial cells relative to cells induced to undergo EMT by Twist1. |
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Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 36% |
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Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 9% |
Student > Doctoral Student | 7 | 8% |
Other | 19 | 22% |
Unknown | 9 | 10% |
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Immunology and Microbiology | 1 | 1% |
Other | 3 | 3% |
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