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Prefrontal-parietal effective connectivity during working memory in older adults

Overview of attention for article published in Neurobiology of Aging, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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1 news outlet
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3 X users

Citations

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29 Dimensions

Readers on

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70 Mendeley
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Title
Prefrontal-parietal effective connectivity during working memory in older adults
Published in
Neurobiology of Aging, May 2017
DOI 10.1016/j.neurobiolaging.2017.05.005
Pubmed ID
Authors

Stephan Heinzel, Robert C. Lorenz, Quynh-Lam Duong, Michael A. Rapp, Lorenz Deserno

Abstract

Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM) load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20-32 years) and 32 older (60-75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age- and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 20%
Student > Master 12 17%
Student > Ph. D. Student 10 14%
Student > Bachelor 5 7%
Student > Doctoral Student 2 3%
Other 7 10%
Unknown 20 29%
Readers by discipline Count As %
Psychology 19 27%
Neuroscience 15 21%
Medicine and Dentistry 3 4%
Agricultural and Biological Sciences 2 3%
Computer Science 1 1%
Other 6 9%
Unknown 24 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2023.
All research outputs
#3,139,779
of 25,382,440 outputs
Outputs from Neurobiology of Aging
#950
of 4,418 outputs
Outputs of similar age
#54,612
of 325,190 outputs
Outputs of similar age from Neurobiology of Aging
#31
of 96 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,190 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.