| Title |
The Impact of Disease and Drugs on Hip Fracture Risk
|
|---|---|
| Published in |
Calcified Tissue International, September 2016
|
| DOI | 10.1007/s00223-016-0194-7 |
| Pubmed ID | |
| Authors |
Breiffni Leavy, Karl Michaëlsson, Anna Cristina Åberg, Håkan Melhus, Liisa Byberg |
| Abstract |
We report the risks of a comprehensive range of disease and drug categories on hip fracture occurrence using a strict population-based cohort design. Participants included the source population of a Swedish county, aged ≥50 years (n = 117,494) including all incident hip fractures during 1 year (n = 477). The outcome was hospitalization for hip fracture (ICD-10 codes S72.0-S72.2) during 1 year (2009-2010). Exposures included: prevalence of (1) inpatient diseases [International Classification of Diseases (ICD) codes A00-T98 in the National Patient Register 1987-2010] and (2) prescribed drugs dispensed in 2010 or the year prior to fracture. We present age- and sex-standardized risk ratios (RRs), risk differences (RDs) and population attributable risks (PARs) of disease and drug categories in relation to hip fracture risk. All disease categories were associated with increased risk of hip fracture. Largest risk ratios and differences were for mental and behavioral disorders, diseases of the blood and previous fracture (RRs between 2.44 and 3.00; RDs (per 1000 person-years) between 5.0 and 6.9). For specific drugs, strongest associations were seen for antiparkinson (RR 2.32 [95 % CI 1.48-1.65]; RD 5.2 [1.1-9.4]) and antidepressive drugs (RR 1.90 [1.55-2.32]; RD 3.1 [2.0-4.3]). Being prescribed ≥10 drugs during 1 year incurred an increased risk of hip fracture, whereas prescription of cardiovascular drugs or ≤5 drugs did not appear to increase risk. Diseases inferring the greatest PARs included: cardiovascular diseases PAR 22 % (95 % CI 14-29) and previous injuries (PAR 21 % [95 % CI 16-25]; for specific drugs, antidepressants posed the greatest risk (PAR 16 % [95 % CI 12.0-19.3]). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 19% |
| Student > Bachelor | 7 | 13% |
| Student > Ph. D. Student | 7 | 13% |
| Other | 3 | 6% |
| Student > Master | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 15 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 36% |
| Nursing and Health Professions | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Arts and Humanities | 1 | 2% |
| Environmental Science | 1 | 2% |
| Other | 5 | 9% |
| Unknown | 17 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2017.
All research outputs
#15,459,013
of 22,971,207 outputs
Outputs from Calcified Tissue International
#1,356
of 1,778 outputs
Outputs of similar age
#205,071
of 323,216 outputs
Outputs of similar age from Calcified Tissue International
#10
of 15 outputs
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So far Altmetric has tracked 1,778 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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