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The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

Overview of attention for article published in Nucleic Acids Research, December 2013
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Title
The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival
Published in
Nucleic Acids Research, December 2013
DOI 10.1093/nar/gkt1307
Pubmed ID
Authors

Chiara Naro, Federica Barbagallo, Paolo Chieffi, Cyril F. Bourgeois, Maria Paola Paronetto, Claudio Sette

Abstract

NEK2 is a serine/threonine kinase that promotes centrosome splitting and ensures correct chromosome segregation during the G2/M phase of the cell cycle, through phosphorylation of specific substrates. Aberrant expression and activity of NEK2 in cancer cells lead to dysregulation of the centrosome cycle and aneuploidy. Thus, a tight regulation of NEK2 function is needed during cell cycle progression. In this study, we found that NEK2 localizes in the nucleus of cancer cells derived from several tissues. In particular, NEK2 co-localizes in splicing speckles with SRSF1 and SRSF2. Moreover, NEK2 interacts with several splicing factors and phosphorylates some of them, including the oncogenic SRSF1 protein. Overexpression of NEK2 induces phosphorylation of endogenous SR proteins and affects the splicing activity of SRSF1 toward reporter minigenes and endogenous targets, independently of SRPK1. Conversely, knockdown of NEK2, like that of SRSF1, induces expression of pro-apoptotic variants from SRSF1-target genes and sensitizes cells to apoptosis. Our results identify NEK2 as a novel splicing factor kinase and suggest that part of its oncogenic activity may be ascribed to its ability to modulate alternative splicing, a key step in gene expression regulation that is frequently altered in cancer cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
United Kingdom 1 2%
Sweden 1 2%
Unknown 60 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 19%
Student > Bachelor 8 13%
Researcher 8 13%
Student > Master 7 11%
Other 4 6%
Other 9 14%
Unknown 15 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 38%
Agricultural and Biological Sciences 17 27%
Medicine and Dentistry 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 3%
Unknown 15 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2015.
All research outputs
#7,105,165
of 22,738,543 outputs
Outputs from Nucleic Acids Research
#11,984
of 26,316 outputs
Outputs of similar age
#87,319
of 306,712 outputs
Outputs of similar age from Nucleic Acids Research
#170
of 333 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 26,316 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,712 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 333 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.