| Title |
Beyond immunomodulation: The regenerative role for regulatory T cells in central nervous system remyelination
|
|---|---|
| Published in |
Journal of Cell Communication and Signaling, May 2017
|
| DOI | 10.1007/s12079-017-0392-8 |
| Pubmed ID | |
| Authors |
Veronique E. Miron |
| Abstract |
Central nervous system regeneration after injury can occur in the form of remyelination, the reinstatement of myelin around axons which restores axon health and function. However, remyelination often fails in chronic neurological diseases, such as progressive multiple sclerosis. The lack of currently approved pro-remyelination therapies highlights the need to elucidate the cellular and molecular mechanisms underpinning this regenerative process. Whereas some T lymphocyte subsets such as Th1 and Th17 are implicated in inducing myelin injury, a recent study by Dombrowski et al. reveals a novel role for regulatory T cells (Tregs) in directly driving remyelination, independent of immunomodulation (Nat Neurosci doi: 10.1038/nn.4528 2017)(Dombrowski et al., 2017). This study is summarized in this Bits and Bytes. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 25% |
| United Kingdom | 2 | 25% |
| Canada | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
| Scientists | 1 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 27 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 21% |
| Student > Ph. D. Student | 4 | 14% |
| Professor > Associate Professor | 3 | 11% |
| Researcher | 3 | 11% |
| Other | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 10 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 21% |
| Medicine and Dentistry | 3 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Immunology and Microbiology | 2 | 7% |
| Psychology | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 11 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2017.
All research outputs
#6,125,821
of 22,971,207 outputs
Outputs from Journal of Cell Communication and Signaling
#42
of 268 outputs
Outputs of similar age
#97,002
of 310,860 outputs
Outputs of similar age from Journal of Cell Communication and Signaling
#2
of 6 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 268 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,860 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.