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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration
|
|---|---|
| Published in |
Cell Reports, December 2013
|
| DOI | 10.1016/j.celrep.2013.12.004 |
| Pubmed ID | |
| Authors |
Brent Neumann, Massimo A. Hilliard |
| Abstract |
Axonal degeneration arises as a consequence of neuronal injury and is a common hallmark of a number of neurodegenerative diseases. However, the genetic causes and the cellular mechanisms that trigger this process are still largely unknown. Based on forward genetic screening in C. elegans, we have identified the α-tubulin acetyltransferase gene mec-17 as causing spontaneous, adult-onset, and progressive axonal degeneration. Loss of MEC-17 leads to microtubule instability, a reduction in mitochondrial number, and disrupted axonal transport, with altered distribution of both mitochondria and synaptic components. Furthermore, mec-17-mediated axonal degeneration occurs independently from its acetyltransferase domain; is enhanced by mutation of coel-1, a tubulin-associated molecule; and correlates with the animal's body length. This study therefore identifies a critical role for the conserved microtubule-associated protein MEC-17 in preserving axon integrity and preventing axonal degeneration. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 43% |
| New Zealand | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 109 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 30% |
| Researcher | 19 | 17% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 8 | 7% |
| Professor > Associate Professor | 8 | 7% |
| Other | 19 | 17% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 35% |
| Biochemistry, Genetics and Molecular Biology | 23 | 20% |
| Neuroscience | 16 | 14% |
| Medicine and Dentistry | 6 | 5% |
| Engineering | 5 | 4% |
| Other | 9 | 8% |
| Unknown | 15 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2021.
All research outputs
#1,186,501
of 25,374,647 outputs
Outputs from Cell Reports
#2,741
of 12,956 outputs
Outputs of similar age
#12,787
of 320,112 outputs
Outputs of similar age from Cell Reports
#13
of 137 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,956 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.