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Trends of Neonatal Abstinence Syndrome Epidemic and Maternal Risk Factors in Florida

Overview of attention for article published in Pharmacotherapy, June 2017
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Title
Trends of Neonatal Abstinence Syndrome Epidemic and Maternal Risk Factors in Florida
Published in
Pharmacotherapy, June 2017
DOI 10.1002/phar.1947
Pubmed ID
Authors

Xi Wang, Yanmin Zhu, Chintan V. Dave, Adel A. Alrwisan, Stacy A. Voils, Almut G. Winterstein

Abstract

This study aimed to examine secular trends of (i) maternal prescription opioid use in late pregnancy, (ii) neonatal abstinence syndrome (NAS) stratified by late maternal prescription opioid use, and (iii) maternal risk factors among NAS deliveries. Women with a live birth who were enrolled 90 days before and 30 days after delivery in Florida Medicaid Analytic Extract billing records linked to birth certificates from 2000 to 2010 were identified for the study. Changes in the annual prevalence of prescription opioid use during pregnancy were tested with the Cochran-Armitage trend test. Temporal trends of NAS deliveries were estimated with Poisson regression and stratified by prescription opioids exposure in the last 90 days of pregnancy in the study period. To identify contributors to the increase in NAS cases, variation in prevalence of opioid dispensing, tobacco use, antidepressant use, and substance use disorder among NAS and non-NAS deliveries were examined. There were 41,968 (9.4%) deliveries exposed to at least one opioid prescription in late pregnancy, which remained stable from 2000 to 2010. Among prescription opioid-exposed deliveries, frequency of NAS increased from 1.6 to 25.2 per 1000 live-births during the study period (P<0.05). Although the prevalence of maternal use of prescription opioid, tobacco, and antidepressant remained stable among NAS deliveries from 2000 to 2010, the prevalence of substance use disorder diagnoses increased substantially from 38.9% in 2000 to 67.9% in 2006 (P<0.05). The prevalence of neonatal abstinence syndrome increased dramatically whereas the prevalence of major risk factors, including maternal prescription opioid use, remained stable in Florida between 2000 to 2010. The increase in substance use disorder may be responsible for the sharp increase in NAS deliveries. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 13%
Researcher 7 13%
Student > Bachelor 7 13%
Student > Doctoral Student 6 11%
Student > Ph. D. Student 4 8%
Other 11 21%
Unknown 11 21%
Readers by discipline Count As %
Medicine and Dentistry 12 23%
Social Sciences 9 17%
Pharmacology, Toxicology and Pharmaceutical Science 6 11%
Nursing and Health Professions 5 9%
Psychology 3 6%
Other 4 8%
Unknown 14 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Pharmacotherapy
#2,207
of 2,502 outputs
Outputs of similar age
#239,203
of 329,969 outputs
Outputs of similar age from Pharmacotherapy
#47
of 55 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,502 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.