Title |
Therapeutic targeting of EPH receptors and their ligands
|
---|---|
Published in |
Nature Reviews Drug Discovery, December 2013
|
DOI | 10.1038/nrd4175 |
Pubmed ID | |
Authors |
Andrew W. Boyd, Perry F. Bartlett, Martin Lackmann |
Abstract |
Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | 1% |
United States | 3 | 1% |
Singapore | 1 | <1% |
Brazil | 1 | <1% |
Japan | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 246 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 67 | 26% |
Student > Ph. D. Student | 59 | 23% |
Student > Master | 22 | 9% |
Student > Bachelor | 22 | 9% |
Student > Doctoral Student | 18 | 7% |
Other | 34 | 13% |
Unknown | 34 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 76 | 30% |
Biochemistry, Genetics and Molecular Biology | 47 | 18% |
Medicine and Dentistry | 36 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 7% |
Chemistry | 16 | 6% |
Other | 23 | 9% |
Unknown | 40 | 16% |