↓ Skip to main content

Heritability of brain volumes in older adults: the Older Australian Twins Study

Overview of attention for article published in Neurobiology of Aging, October 2013
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
167 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Heritability of brain volumes in older adults: the Older Australian Twins Study
Published in
Neurobiology of Aging, October 2013
DOI 10.1016/j.neurobiolaging.2013.10.079
Pubmed ID
Authors

Seyed Amir Hossein Batouli, Perminder S. Sachdev, Wei Wen, Margaret J. Wright, David Ames, Julian N. Trollor

Abstract

The relative contributions of genetic and environmental factors to brain structure change throughout the lifespan. Brain structures have been reported to be highly heritable in middle-aged individuals and younger; however, the influence of genes on brain structure is less studied in older adults. We performed a magnetic resonance imaging study of 236 older twins, with a mean age of 71.4 ± 5.7 years, to examine the heritability of 53 brain global and lobar volumetric measures. Total brain volume (63%) and other volumetric measures were moderately to highly heritable in late life, and these genetic influences tended to decrease with age, suggesting a greater influence of environmental factors as age advanced. Genetic influences were higher in men and on the left hemisphere compared with the right. In multivariate models, common genetic factors were observed for global and lobar total and gray matter volumes. This study examined the genetic contribution to 53 brain global and lobar volumetric measures in older twins for the first time, and the influence of age, sex, and laterality on these genetic contributions, which are useful information for a better understanding of the process of brain aging and helping individuals to have a healthy aging.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 1 <1%
Unknown 164 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 6%
Student > Ph. D. Student 6 4%
Student > Master 6 4%
Other 4 2%
Student > Doctoral Student 4 2%
Other 8 5%
Unknown 129 77%
Readers by discipline Count As %
Neuroscience 9 5%
Medicine and Dentistry 8 5%
Psychology 8 5%
Biochemistry, Genetics and Molecular Biology 2 1%
Computer Science 2 1%
Other 6 4%
Unknown 132 79%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Neurobiology of Aging
#4,224
of 4,418 outputs
Outputs of similar age
#199,038
of 224,556 outputs
Outputs of similar age from Neurobiology of Aging
#72
of 77 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,556 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.