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Transposon‐driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution

Overview of attention for article published in EMBO Reports, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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1 blog
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30 X users
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1 Facebook page

Citations

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37 Dimensions

Readers on

mendeley
101 Mendeley
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2 CiteULike
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Title
Transposon‐driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution
Published in
EMBO Reports, May 2017
DOI 10.15252/embr.201744059
Pubmed ID
Authors

Matthew P Davis, Claudia Carrieri, Harpreet K Saini, Stijn van Dongen, Tommaso Leonardi, Giovanni Bussotti, Jack M Monahan, Tania Auchynnikava, Angelo Bitetti, Juri Rappsilber, Robin C Allshire, Alena Shkumatava, Dónal O'Carroll, Anton J Enright

Abstract

Spermatogenesis is associated with major and unique changes to chromosomes and chromatin. Here, we sought to understand the impact of these changes on spermatogenic transcriptomes. We show that long terminal repeats (LTRs) of specific mouse endogenous retroviruses (ERVs) drive the expression of many long non-coding transcripts (lncRNA). This process occurs post-mitotically predominantly in spermatocytes and round spermatids. We demonstrate that this transposon-driven lncRNA expression is a conserved feature of vertebrate spermatogenesis. We propose that transposon promoters are a mechanism by which the genome can explore novel transcriptional substrates, increasing evolutionary plasticity and allowing for the genesis of novel coding and non-coding genes. Accordingly, we show that a small fraction of these novel ERV-driven transcripts encode short open reading frames that produce detectable peptides. Finally, we find that distinct ERV elements from the same subfamilies act as differentially activated promoters in a tissue-specific context. In summary, we demonstrate that LTRs can act as tissue-specific promoters and contribute to post-mitotic spermatogenic transcriptome diversity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 100 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 29%
Student > Ph. D. Student 25 25%
Student > Bachelor 6 6%
Student > Master 6 6%
Student > Doctoral Student 4 4%
Other 10 10%
Unknown 21 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 41 41%
Agricultural and Biological Sciences 30 30%
Medicine and Dentistry 3 3%
Neuroscience 3 3%
Computer Science 1 <1%
Other 4 4%
Unknown 19 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2018.
All research outputs
#1,526,653
of 25,402,528 outputs
Outputs from EMBO Reports
#472
of 4,072 outputs
Outputs of similar age
#29,151
of 324,670 outputs
Outputs of similar age from EMBO Reports
#8
of 58 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,072 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,670 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.