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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A role for the neurexin–neuroligin complex in Alzheimer's disease
|
|---|---|
| Published in |
Neurobiology of Aging, November 2013
|
| DOI | 10.1016/j.neurobiolaging.2013.09.032 |
| Pubmed ID | |
| Authors |
Ikhlas A. Sindi, Rudolph K. Tannenberg, Peter R. Dodd |
| Abstract |
Synaptic damage is a critical hallmark of Alzheimer's disease, and the best correlate with cognitive impairment ante mortem. Synapses, the loci of communication between neurons, are characterized by signature protein combinations arrayed at tightly apposed pre- and post-synaptic sites. The most widely studied trans-synaptic junctional complexes, which direct synaptogenesis and foster the maintenance and stability of the mature terminal, are conjunctions of presynaptic neurexins and postsynaptic neuroligins. Fluctuations in the levels of neuroligins and neurexins can sway the balance between excitatory and inhibitory neurotransmission in the brain, and could lead to damage of synapses and dendrites. This review summarizes current understanding of the roles of neurexins and neuroligins proteolytic processing in synaptic plasticity in the human brain, and outlines their possible roles in β-amyloid metabolism and function, which are central pathogenic events in Alzheimer's disease progression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Israel | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 142 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 21% |
| Researcher | 27 | 18% |
| Student > Bachelor | 26 | 18% |
| Student > Master | 13 | 9% |
| Student > Postgraduate | 8 | 5% |
| Other | 20 | 14% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 32% |
| Biochemistry, Genetics and Molecular Biology | 21 | 14% |
| Neuroscience | 20 | 14% |
| Medicine and Dentistry | 18 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 12 | 8% |
| Unknown | 25 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#7,356,343
of 25,374,917 outputs
Outputs from Neurobiology of Aging
#2,385
of 4,418 outputs
Outputs of similar age
#64,609
of 228,664 outputs
Outputs of similar age from Neurobiology of Aging
#32
of 79 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,664 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.