| Title |
Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+T lymphocytes
|
|---|---|
| Published in |
Retrovirology, March 2008
|
| DOI | 10.1186/1742-4690-5-30 |
| Pubmed ID | |
| Authors |
Corinne Barat, Caroline Gilbert, Michael Imbeault, Michel J Tremblay |
| Abstract |
Dendritic cells (DCs) are considered as key mediators of the early events in human immunodeficiency virus type 1 (HIV-1) infection at mucosal sites. Previous studies have shown that surface-bound virions and/or internalized viruses found in endocytic vacuoles of DCs are efficiently transferred to CD4+ T cells. Extracellular adenosine triphosphate (ATP) either secreted or released from necrotic cells induces a distorted maturation of DCs, transiently increases their endocytic capacity and affects their migratory capacity. Knowing that high extracellular ATP concentrations are present in situations of tissue injury and inflammation, we investigated the effect of ATP on HIV-1 transmission from DCs to CD4+ T lymphocytes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 30% |
| Researcher | 5 | 22% |
| Student > Doctoral Student | 2 | 9% |
| Professor > Associate Professor | 2 | 9% |
| Lecturer | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 48% |
| Immunology and Microbiology | 3 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Medicine and Dentistry | 2 | 9% |
| Nursing and Health Professions | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 3 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2014.
All research outputs
#16,722,190
of 25,374,917 outputs
Outputs from Retrovirology
#822
of 1,273 outputs
Outputs of similar age
#81,498
of 95,473 outputs
Outputs of similar age from Retrovirology
#5
of 7 outputs
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So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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