| Title |
Sorting Through the Roles of Beclin 1 in Microglia and Neurodegeneration
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, January 2014
|
| DOI | 10.1007/s11481-013-9519-8 |
| Pubmed ID | |
| Authors |
Caitlin E. O’Brien, Tony Wyss-Coray |
| Abstract |
Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer's Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 7% |
| India | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 39 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 32% |
| Researcher | 12 | 27% |
| Student > Bachelor | 5 | 11% |
| Student > Master | 3 | 7% |
| Professor | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 2 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 43% |
| Neuroscience | 6 | 14% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Medicine and Dentistry | 4 | 9% |
| Psychology | 2 | 5% |
| Other | 5 | 11% |
| Unknown | 3 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2014.
All research outputs
#21,699,788
of 24,217,893 outputs
Outputs from Journal of Neuroimmune Pharmacology
#515
of 583 outputs
Outputs of similar age
#275,698
of 313,943 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#6
of 6 outputs
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