| Title |
Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype?
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, March 2007
|
| DOI | 10.1007/s10803-006-0353-1 |
| Pubmed ID | |
| Authors |
Paul Ashwood, Christina Kwong, Robin Hansen, Irva Hertz-Picciotto, Lisa Croen, Paula Krakowiak, Wynn Walker, Isaac N. Pessah, Judy Van de Water |
| Abstract |
There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p<.006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p<.042), TD controls (p<.0015), and DD controls (p<.004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 96 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 18% |
| Student > Ph. D. Student | 17 | 17% |
| Researcher | 15 | 15% |
| Other | 8 | 8% |
| Professor | 7 | 7% |
| Other | 20 | 20% |
| Unknown | 16 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 26% |
| Agricultural and Biological Sciences | 12 | 12% |
| Neuroscience | 11 | 11% |
| Psychology | 11 | 11% |
| Nursing and Health Professions | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2019.
All research outputs
#4,227,469
of 25,654,806 outputs
Outputs from Journal of Autism and Developmental Disorders
#1,671
of 5,484 outputs
Outputs of similar age
#13,901
of 90,105 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#4
of 12 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,484 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,105 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.