| Title |
Toxoplasma gondii and schizophrenia: a review of published RCTs
|
|---|---|
| Published in |
Parasitology Research, May 2017
|
| DOI | 10.1007/s00436-017-5478-y |
| Pubmed ID | |
| Authors |
Sam D. Chorlton |
| Abstract |
Over the last 60 years, accumulating evidence has suggested that acute, chronic, and maternal Toxoplasma gondii infections predispose to schizophrenia. More recent evidence suggests that chronically infected patients with schizophrenia present with more severe disease. After acute infection, parasites form walled cysts in the brain, leading to lifelong chronic infection and drug resistance to commonly used antiparasitics. Chronic infection is the most studied and closely linked with development and severity of schizophrenia. There are currently four published randomized controlled trials evaluating antiparasitic drugs, specifically azithromycin, trimethoprim, artemisinin, and artemether, in patients with schizophrenia. No trials have demonstrated a change in psychopathology with adjunctive treatment. Published trials have either selected drugs without evidence against chronic infection or used them at doses too low to reduce brain cyst burden. Furthermore, trials have failed to achieve sufficient power or account for confounders such as previous antipsychotic treatment, sex, age, or rhesus status on antiparasitic effect. There are currently no ongoing trials of anti-Toxoplasma therapy in schizophrenia despite ample evidence to justify further testing. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 16% |
| Student > Ph. D. Student | 13 | 15% |
| Researcher | 10 | 12% |
| Student > Doctoral Student | 8 | 9% |
| Student > Master | 8 | 9% |
| Other | 10 | 12% |
| Unknown | 23 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 21% |
| Neuroscience | 8 | 9% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Agricultural and Biological Sciences | 5 | 6% |
| Immunology and Microbiology | 5 | 6% |
| Other | 13 | 15% |
| Unknown | 29 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2023.
All research outputs
#2,059,271
of 24,244,537 outputs
Outputs from Parasitology Research
#69
of 3,906 outputs
Outputs of similar age
#39,416
of 313,620 outputs
Outputs of similar age from Parasitology Research
#1
of 68 outputs
Altmetric has tracked 24,244,537 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,906 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.