| Title |
Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia
|
|---|---|
| Published in |
Cell and Tissue Research, May 2016
|
| DOI | 10.1007/s00441-016-2414-x |
| Pubmed ID | |
| Authors |
Waclaw Tworzydlo, Elzbieta Kisiel, Wladyslawa Jankowska, Alicja Witwicka, Szczepan M. Bilinski |
| Abstract |
Oocytes of many invertebrate and vertebrate species contain a characteristic organelle complex known as the Balbiani body (Bb). Until now, three principal functions have been ascribed to this complex: delivery of germ cell determinants and localized RNAs to the vegetal cortex/posterior pole of the oocyte, transport of the mitochondria towards the germ plasm, and participation in the formation of lipid droplets. Here, we present the results of a computer-aided 3D reconstruction of the Bb in the growing oocytes of an insect, Thermobia domestica. Our analyses have shown that, in Thermobia, the central part of each fully developed Bb comprises a single intricate mitochondrial network. This "core" network is surrounded by several isolated bean-shaped mitochondrial units that display lowered membrane potential and clear signs of degeneration. In light of the above results and recent theoretical models of mitochondrial quality control, the role of the Bb is discussed. We suggest that, in addition to the aforementioned functions, the Bb is implicated in the selective elimination of dysfunctional mitochondria during oogenesis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 29% |
| Professor > Associate Professor | 4 | 13% |
| Student > Bachelor | 3 | 10% |
| Researcher | 3 | 10% |
| Student > Doctoral Student | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 48% |
| Biochemistry, Genetics and Molecular Biology | 10 | 32% |
| Neuroscience | 1 | 3% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2017.
All research outputs
#19,237,853
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#1,706
of 2,279 outputs
Outputs of similar age
#227,355
of 307,248 outputs
Outputs of similar age from Cell and Tissue Research
#14
of 36 outputs
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