| Title |
l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain
|
|---|---|
| Published in |
Neurochemical Research, May 2017
|
| DOI | 10.1007/s11064-017-2288-7 |
| Pubmed ID | |
| Authors |
Gustavo C. Ferreira, Mary C. McKenna |
| Abstract |
L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. Treatment with L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism. In recent years there has been considerable interest in the therapeutic potential of L-carnitine and its acetylated derivative acetyl-L-carnitine (ALCAR) for neuroprotection in a number of disorders including hypoxia-ischemia, traumatic brain injury, Alzheimer's disease and in conditions leading to central or peripheral nervous system injury. There is compelling evidence from preclinical studies that L-carnitine and ALCAR can improve energy status, decrease oxidative stress and prevent subsequent cell death in models of adult, neonatal and pediatric brain injury. ALCAR can provide an acetyl moiety that can be oxidized for energy, used as a precursor for acetylcholine, or incorporated into glutamate, glutamine and GABA, or into lipids for myelination and cell growth. Administration of ALCAR after brain injury in rat pups improved long-term functional outcomes, including memory. Additional studies are needed to better explore the potential of L-carnitine and ALCAR for protection of developing brain as there is an urgent need for therapies that can improve outcome after neonatal and pediatric brain injury. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 9% |
| Spain | 2 | 9% |
| Germany | 1 | 4% |
| Austria | 1 | 4% |
| France | 1 | 4% |
| India | 1 | 4% |
| Canada | 1 | 4% |
| Italy | 1 | 4% |
| Unknown | 13 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 87% |
| Scientists | 2 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 221 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 12% |
| Researcher | 25 | 11% |
| Student > Master | 22 | 10% |
| Student > Ph. D. Student | 21 | 10% |
| Other | 12 | 5% |
| Other | 38 | 17% |
| Unknown | 76 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 16% |
| Biochemistry, Genetics and Molecular Biology | 25 | 11% |
| Agricultural and Biological Sciences | 16 | 7% |
| Nursing and Health Professions | 12 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 5% |
| Other | 45 | 20% |
| Unknown | 76 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 127. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#332,994
of 26,017,215 outputs
Outputs from Neurochemical Research
#6
of 2,334 outputs
Outputs of similar age
#6,854
of 329,291 outputs
Outputs of similar age from Neurochemical Research
#1
of 52 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,334 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,291 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.