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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Δ‐Myrtoxin‐Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane‐Disrupting, and Nociceptive Activities
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, June 2017
|
| DOI | 10.1002/anie.201703360 |
| Pubmed ID | |
| Authors |
Zoltan Dekan, Stephen J. Headey, Martin Scanlon, Brian A. Baldo, Tzong‐Hsien Lee, Marie‐Isabel Aguilar, Jennifer R. Deuis, Irina Vetter, Alysha G. Elliott, Maite Amado, Matthew A. Cooper, Dianne Alewood, Paul F. Alewood |
| Abstract |
Δ-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula is comprised of a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthetic chains via aerial oxidation remarkably resulted in the self-assembly of Mp1a as a homogenous product without the need for directed disulfide bond formation. NMR analysis revealed a well-defined, unique structure containing a pair of antiparallel α-helices. DPI analysis showed strong interaction with supported lipid bilayers and insertion within the bilayers. Mp1a caused non-specific calcium influx in SH-SY5Y cells with an EC50 of 4.3 µM. Mp1a also displayed broad-spectrum antimicrobial activity, with the highest potency against Gram-negative A. baumannii (MIC 25 nM). Intraplantar injection (10 µM) in mice elicited spontaneous pain and mechanical allodynia. Single and two chain mimetics of Mp1a revealed functionally selectivity. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 40% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 80% |
| Members of the public | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 25% |
| Professor > Associate Professor | 5 | 14% |
| Researcher | 4 | 11% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 36% |
| Agricultural and Biological Sciences | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Immunology and Microbiology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 10 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2017.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from Angewandte Chemie. International Edition
#33,330
of 50,001 outputs
Outputs of similar age
#173,052
of 331,711 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#575
of 838 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 50,001 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 838 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.