Title |
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer
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Published in |
Pediatric Blood and Cancer, January 2014
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DOI | 10.1002/pbc.24921 |
Pubmed ID | |
Authors |
Mette Levinsen, Elisabeth Ørskov Rotevatn, Susanne Rosthøj, Jacob Nersting, Jonas Abrahamsson, Malin Lindqvist Appell, Stein Bergan, Anne‐Grete Bechensteen, Arja Harila‐Saari, Mats Heyman, Olafur Gisli Jonsson, Jakob Bernhard Cohn Maxild, Mikko Niemi, Stefan Söderhäll, Kjeld Schmiegelow, Oncology for the Nordic Society of Paediatric Haematology |
Abstract |
Previous studies have indicated that patients with thiopurine methyltransferase (TPMT) low activity (TPMT(LA)) have reduced risk of relapse but increased risk of second malignant neoplasm (SMN) compared to patients with TPMT wild-type (TPMT(WT)) when treated with 6 MP maintenance therapy starting doses of 75 mg/m(2)/day. To reduce SMN risk, 6MP starting doses were reduced to 50 mg/m(2)/day for patients with TPMT heterozygosity in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2000 protocol. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Finland | 1 | 2% |
Spain | 1 | 2% |
Serbia | 1 | 2% |
Unknown | 38 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 20% |
Professor > Associate Professor | 5 | 12% |
Student > Master | 4 | 10% |
Student > Ph. D. Student | 3 | 7% |
Other | 3 | 7% |
Other | 11 | 27% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 9 | 22% |
Agricultural and Biological Sciences | 4 | 10% |
Nursing and Health Professions | 1 | 2% |
Arts and Humanities | 1 | 2% |
Other | 2 | 5% |
Unknown | 7 | 17% |