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Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer

Overview of attention for article published in Pediatric Blood and Cancer, January 2014
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  • Average Attention Score compared to outputs of the same age and source

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Citations

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26 Dimensions

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41 Mendeley
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1 CiteULike
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Title
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer
Published in
Pediatric Blood and Cancer, January 2014
DOI 10.1002/pbc.24921
Pubmed ID
Authors

Mette Levinsen, Elisabeth Ørskov Rotevatn, Susanne Rosthøj, Jacob Nersting, Jonas Abrahamsson, Malin Lindqvist Appell, Stein Bergan, Anne‐Grete Bechensteen, Arja Harila‐Saari, Mats Heyman, Olafur Gisli Jonsson, Jakob Bernhard Cohn Maxild, Mikko Niemi, Stefan Söderhäll, Kjeld Schmiegelow, Oncology for the Nordic Society of Paediatric Haematology

Abstract

Previous studies have indicated that patients with thiopurine methyltransferase (TPMT) low activity (TPMT(LA)) have reduced risk of relapse but increased risk of second malignant neoplasm (SMN) compared to patients with TPMT wild-type (TPMT(WT)) when treated with 6 MP maintenance therapy starting doses of 75 mg/m(2)/day. To reduce SMN risk, 6MP starting doses were reduced to 50 mg/m(2)/day for patients with TPMT heterozygosity in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2000 protocol.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 2%
Spain 1 2%
Serbia 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 20%
Professor > Associate Professor 5 12%
Student > Master 4 10%
Student > Ph. D. Student 3 7%
Other 3 7%
Other 11 27%
Unknown 7 17%
Readers by discipline Count As %
Medicine and Dentistry 17 41%
Pharmacology, Toxicology and Pharmaceutical Science 9 22%
Agricultural and Biological Sciences 4 10%
Nursing and Health Professions 1 2%
Arts and Humanities 1 2%
Other 2 5%
Unknown 7 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2014.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Pediatric Blood and Cancer
#3,330
of 6,048 outputs
Outputs of similar age
#202,521
of 318,781 outputs
Outputs of similar age from Pediatric Blood and Cancer
#38
of 79 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,048 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,781 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.