| Title |
The excitation–contraction coupling mechanism in skeletal muscle
|
|---|---|
| Published in |
Biophysical Reviews, January 2014
|
| DOI | 10.1007/s12551-013-0135-x |
| Pubmed ID | |
| Authors |
Juan C. Calderón, Pura Bolaños, Carlo Caputo |
| Abstract |
First coined by Alexander Sandow in 1952, the term excitation-contraction coupling (ECC) describes the rapid communication between electrical events occurring in the plasma membrane of skeletal muscle fibres and Ca(2+) release from the SR, which leads to contraction. The sequence of events in twitch skeletal muscle involves: (1) initiation and propagation of an action potential along the plasma membrane, (2) spread of the potential throughout the transverse tubule system (T-tubule system), (3) dihydropyridine receptors (DHPR)-mediated detection of changes in membrane potential, (4) allosteric interaction between DHPR and sarcoplasmic reticulum (SR) ryanodine receptors (RyR), (5) release of Ca(2+) from the SR and transient increase of Ca(2+) concentration in the myoplasm, (6) activation of the myoplasmic Ca(2+) buffering system and the contractile apparatus, followed by (7) Ca(2+) disappearance from the myoplasm mediated mainly by its reuptake by the SR through the SR Ca(2+) adenosine triphosphatase (SERCA), and under several conditions movement to the mitochondria and extrusion by the Na(+)/Ca(2+) exchanger (NCX). In this text, we review the basics of ECC in skeletal muscle and the techniques used to study it. Moreover, we highlight some recent advances and point out gaps in knowledge on particular issues related to ECC such as (1) DHPR-RyR molecular interaction, (2) differences regarding fibre types, (3) its alteration during muscle fatigue, (4) the role of mitochondria and store-operated Ca(2+) entry in the general ECC sequence, (5) contractile potentiators, and (6) Ca(2+) sparks. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 15% |
| United States | 2 | 15% |
| South Africa | 1 | 8% |
| United Kingdom | 1 | 8% |
| Chile | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 4 | 31% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Ireland | 1 | <1% |
| Unknown | 332 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 63 | 19% |
| Student > Ph. D. Student | 56 | 17% |
| Student > Master | 51 | 15% |
| Researcher | 22 | 7% |
| Student > Doctoral Student | 12 | 4% |
| Other | 37 | 11% |
| Unknown | 93 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 57 | 17% |
| Medicine and Dentistry | 36 | 11% |
| Sports and Recreations | 34 | 10% |
| Agricultural and Biological Sciences | 31 | 9% |
| Engineering | 15 | 4% |
| Other | 53 | 16% |
| Unknown | 108 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2023.
All research outputs
#1,938,270
of 25,457,297 outputs
Outputs from Biophysical Reviews
#18
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Outputs of similar age
#21,720
of 321,334 outputs
Outputs of similar age from Biophysical Reviews
#2
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