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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Overview of attention for article published in Genes & Development, January 2014
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
patent
1 patent

Citations

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156 Dimensions

Readers on

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105 Mendeley
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1 CiteULike
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Title
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Published in
Genes & Development, January 2014
DOI 10.1101/gad.232009.113
Pubmed ID
Authors

Gemma L. Kelly, Stephanie Grabow, Stefan P. Glaser, Leah Fitzsimmons, Brandon J. Aubrey, Toru Okamoto, Liz J. Valente, Mikara Robati, Lin Tai, W. Douglas Fairlie, Erinna F. Lee, Mikael S. Lindstrom, Klas G. Wiman, David C.S. Huang, Philippe Bouillet, Martin Rowe, Alan B. Rickinson, Marco J. Herold, Andreas Strasser

Abstract

The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis is critical for cancer development, particularly c-MYC-driven cancers. We explored which anti-apoptotic BCL-2 family member (expressed under endogenous regulation) is essential to sustain c-MYC-driven lymphoma growth to reveal which should be targeted for cancer therapy. Remarkably, inducible Cre-mediated deletion of even a single Mcl-1 allele substantially impaired the growth of c-MYC-driven mouse lymphomas. Mutations in p53 could diminish but not obviate the dependency of c-MYC-driven mouse lymphomas on MCL-1. Importantly, targeting of MCL-1 killed c-MYC-driven human Burkitt lymphoma cells, even those bearing mutations in p53. Given that loss of one allele of Mcl-1 is well tolerated in healthy tissues, our results suggest that therapeutic targeting of MCL-1 would be an attractive therapeutic strategy for MYC-driven cancers.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Australia 1 <1%
Unknown 101 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 24%
Researcher 25 24%
Student > Bachelor 8 8%
Student > Doctoral Student 7 7%
Other 7 7%
Other 15 14%
Unknown 18 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 36%
Biochemistry, Genetics and Molecular Biology 21 20%
Medicine and Dentistry 14 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Immunology and Microbiology 5 5%
Other 3 3%
Unknown 19 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2020.
All research outputs
#6,934,754
of 22,739,983 outputs
Outputs from Genes & Development
#3,013
of 5,833 outputs
Outputs of similar age
#82,991
of 304,804 outputs
Outputs of similar age from Genes & Development
#27
of 50 outputs
Altmetric has tracked 22,739,983 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 5,833 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,804 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.