| Title |
α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release
|
|---|---|
| Published in |
Molecular Medicine, May 2014
|
| DOI | 10.2119/molmed.2013.00117 |
| Pubmed ID | |
| Authors |
Ben Lu, Kevin Kwan, Yaakov A. Levine, Peder S. Olofsson, Huan Yang, Jianhua Li, Sonia Joshi, Haichao Wang, Ulf Andersson, Sangeeta S. Chavan, Kevin J. Tracey |
| Abstract |
The mammalian immune system and the nervous system coevolved under the influence of cellular and environmental stress. Cellular stress is associated with changes in immunity and activation of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, a key component of innate immunity. Here we show that α7 nicotinic acetylcholine receptor (α7 nAchR)-signaling inhibits inflammasome activation and prevents release of mitochondrial DNA, an NLRP3 ligand. Cholinergic receptor agonists or vagus nerve stimulation significantly inhibits inflammasome activation, whereas genetic deletion of α7 nAchR significantly enhances inflammasome activation. Acetylcholine accumulates in macrophage cytoplasm after adenosine triphosphate (ATP) stimulation in an α7 nAchR-independent manner. Acetylcholine significantly attenuated calcium or hydrogen oxide-induced mitochondrial damage and mitochondrial DNA release. Together, these findings reveal a novel neurotransmitter-mediated signaling pathway: acetylcholine translocates into the cytoplasm of immune cells during inflammation and inhibits NLRP3 inflammasome activation by preventing mitochondrial DNA release. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 22% |
| Researcher | 23 | 16% |
| Student > Bachelor | 14 | 10% |
| Student > Master | 13 | 9% |
| Professor | 10 | 7% |
| Other | 25 | 17% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 18% |
| Immunology and Microbiology | 24 | 16% |
| Agricultural and Biological Sciences | 21 | 14% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Neuroscience | 12 | 8% |
| Other | 14 | 10% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2023.
All research outputs
#6,602,154
of 23,351,247 outputs
Outputs from Molecular Medicine
#320
of 1,163 outputs
Outputs of similar age
#62,367
of 228,299 outputs
Outputs of similar age from Molecular Medicine
#3
of 7 outputs
Altmetric has tracked 23,351,247 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,163 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,299 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.