Title |
High Serum miR-19a Levels Are Associated with Inflammatory Breast Cancer and Are Predictive of Favorable Clinical Outcome in Patients with Metastatic HER2+ Inflammatory Breast Cancer
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Published in |
PLOS ONE, January 2014
|
DOI | 10.1371/journal.pone.0083113 |
Pubmed ID | |
Authors |
Simone Anfossi, Antonio Giordano, Hui Gao, Evan N. Cohen, Sanda Tin, Qiong Wu, Raul J. Garza, Bisrat G. Debeb, Ricardo H. Alvarez, Vicente Valero, Gabriel N. Hortobagyi, George A. Calin, Naoto T. Ueno, Wendy A. Woodward, James M. Reuben |
Abstract |
Altered serum microRNA (miRNA) levels may be correlated with a dysregulated expression pattern in parental tumor tissue and reflect the clinical evolution of disease. The overexpression of miR-21, miR-10b, and miR-19a is associated with the acquisition of malignant characteristics (increased tumor cell proliferation, migration, invasion, dissemination, and metastasis); thus, we determined their utility as serum biomarkers for aggressive breast cancer (HER2-overexpressed or -amplified [HER2(+)] and inflammatory breast cancer [IBC]). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 2% |
Denmark | 1 | 2% |
Egypt | 1 | 2% |
Unknown | 61 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 22% |
Student > Ph. D. Student | 11 | 17% |
Student > Bachelor | 6 | 9% |
Student > Master | 5 | 8% |
Professor > Associate Professor | 4 | 6% |
Other | 9 | 14% |
Unknown | 15 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 20% |
Medicine and Dentistry | 12 | 19% |
Agricultural and Biological Sciences | 10 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Chemistry | 2 | 3% |
Other | 5 | 8% |
Unknown | 19 | 30% |