Title |
The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study
|
---|---|
Published in |
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, May 2017
|
DOI | 10.1016/j.jalz.2017.04.004 |
Pubmed ID | |
Authors |
Kathleen M. Hayden, Daniel P. Beavers, Susan E. Steck, James R. Hebert, Fred K. Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E. Manson, Claudia B. Padula, Elena Salmoirago‐Blotcher, Linda G. Snetselaar, Oleg Zaslavsky, Stephen R. Rapp |
Abstract |
The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally. Mixed effect models evaluated cognitive decline on over time; Cox models evaluated the risk of MCI or dementia across DII groups. Over an average of 9.7 years, there were 1081 incident cases of cognitive impairment. Higher DII scores were associated with greater cognitive decline and earlier onset of cognitive impairment. Adjusted hazard ratios (HRs) comparing lower (anti-inflammatory; group 1 referent) DII scores to the higher scores were group 2-HR: 1.01 (0.86-1.20); group 3-HR: 0.99 (0.82-1.18); and group 4-HR: 1.27 (1.06-1.52). Diets with the highest pro-inflammatory potential were associated with higher risk of MCI or dementia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 50% |
Japan | 2 | 8% |
Australia | 1 | 4% |
Canada | 1 | 4% |
India | 1 | 4% |
Spain | 1 | 4% |
Unknown | 6 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 67% |
Scientists | 5 | 21% |
Practitioners (doctors, other healthcare professionals) | 3 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Unknown | 196 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 37 | 19% |
Student > Master | 27 | 14% |
Researcher | 17 | 9% |
Student > Ph. D. Student | 11 | 6% |
Student > Doctoral Student | 10 | 5% |
Other | 28 | 14% |
Unknown | 67 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 21% |
Nursing and Health Professions | 29 | 15% |
Psychology | 15 | 8% |
Agricultural and Biological Sciences | 10 | 5% |
Neuroscience | 10 | 5% |
Other | 20 | 10% |
Unknown | 71 | 36% |