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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
|
|---|---|
| Published in |
Free Radical Biology & Medicine, January 2014
|
| DOI | 10.1016/j.freeradbiomed.2013.12.026 |
| Pubmed ID | |
| Authors |
Lili Yang, Raphael Rozenfeld, Defeng Wu, Lakshmi A. Devi, Zhenfeng Zhang, Arthur Cederbaum |
| Abstract |
Acute alcohol drinking induces steatosis, and effective prevention of steatosis can protect liver from progressive damage caused by alcohol. Increased oxidative stress has been reported as one mechanism underlying alcohol-induced steatosis. We evaluated whether cannabidiol, which has been reported to function as an antioxidant, can protect the liver from alcohol-generated oxidative stress-induced steatosis. Cannabidiol can prevent acute alcohol-induced liver steatosis in mice, possibly by preventing the increase in oxidative stress and the activation of the JNK MAPK pathway. Cannabidiol per se can increase autophagy both in CYP2E1-expressing HepG2 cells and in mouse liver. Importantly, cannabidiol can prevent the decrease in autophagy induced by alcohol. In conclusion, these results show that cannabidiol protects mouse liver from acute alcohol-induced steatosis through multiple mechanisms including attenuation of alcohol-mediated oxidative stress, prevention of JNK MAPK activation, and increasing autophagy. |
X Demographics
The data shown below were collected from the profiles of 286 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 61 | 21% |
| Japan | 31 | 11% |
| United Kingdom | 12 | 4% |
| Canada | 8 | 3% |
| Russia | 8 | 3% |
| Australia | 4 | 1% |
| Norway | 3 | 1% |
| Denmark | 2 | <1% |
| Georgia | 2 | <1% |
| Other | 12 | 4% |
| Unknown | 143 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 263 | 92% |
| Scientists | 13 | 5% |
| Practitioners (doctors, other healthcare professionals) | 8 | 3% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Unknown | 151 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 15% |
| Student > Master | 21 | 14% |
| Researcher | 20 | 13% |
| Student > Ph. D. Student | 19 | 12% |
| Professor | 10 | 6% |
| Other | 29 | 19% |
| Unknown | 32 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 19% |
| Agricultural and Biological Sciences | 24 | 16% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 8% |
| Neuroscience | 11 | 7% |
| Other | 20 | 13% |
| Unknown | 42 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 380. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2024.
All research outputs
#83,346
of 25,756,531 outputs
Outputs from Free Radical Biology & Medicine
#8
of 5,494 outputs
Outputs of similar age
#652
of 321,155 outputs
Outputs of similar age from Free Radical Biology & Medicine
#1
of 48 outputs
Altmetric has tracked 25,756,531 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,494 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,155 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.