| Title |
Increased Expression of Brain-Derived Neurotrophic Factor Transcripts I and VI, cAMP Response Element Binding, and Glucocorticoid Receptor in the Cortex of Patients with Temporal Lobe Epilepsy
|
|---|---|
| Published in |
Molecular Neurobiology, May 2017
|
| DOI | 10.1007/s12035-017-0597-0 |
| Pubmed ID | |
| Authors |
G. A. Martínez-Levy, L. Rocha, F. Rodríguez-Pineda, M. A. Alonso-Vanegas, A. Nani, R. M. Buentello-García, M. Briones-Velasco, D. San-Juan, J. Cienfuegos, C. S. Cruz-Fuentes |
| Abstract |
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of BDNF messenger for the exon VI in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. Altered levels of this particular transcript were also associated with pre-surgical use of certain psychotropic. We extended here our analysis of transcripts I, II, IV, and VI to the temporal cortex since this cerebral region holds intrinsic communication with the hippocampus and is structurally affected in patients with TLE. We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy. TLE and pre-surgical pharmacological treatment were considered as the primary clinical independent variables. Transcripts BDNF I and BDNF VI increased in the temporal cortex of patients with pharmacoresistant TLE. The expression of CREB and GR expression follow the same direction. Pre-surgical use of selective serotonin reuptake inhibitors, carbamazepine (CBZ) and valproate (VPA), was associated with the differential expression of specific BDNF transcripts and CREB and GR genes. These changes could have functional implication in the plasticity mechanisms related to temporal lobe epilepsy. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 15% |
| Student > Ph. D. Student | 6 | 15% |
| Other | 5 | 12% |
| Researcher | 4 | 10% |
| Student > Master | 3 | 7% |
| Other | 2 | 5% |
| Unknown | 15 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 17% |
| Medicine and Dentistry | 4 | 10% |
| Engineering | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Chemistry | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 22 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2017.
All research outputs
#15,459,782
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Outputs from Molecular Neurobiology
#2,075
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Outputs of similar age
#196,408
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Outputs of similar age from Molecular Neurobiology
#61
of 125 outputs
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