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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, December 2013
|
| DOI | 10.1016/j.bmcl.2013.12.045 |
| Pubmed ID | |
| Authors |
Núria R. Roqué Rosell, Ladan Mokhlesi, Nicholas E. Milton, Trevor R. Sweeney, Patricia A. Zunszain, Stephen Curry, Robin J. Leatherbarrow |
| Abstract |
Foot-and-mouth disease virus (FMDV) causes a highly infectious and economically devastating disease of livestock. The FMDV genome is translated as a single polypeptide precursor that is cleaved into functional proteins predominantly by the highly conserved viral 3C protease, making this enzyme an attractive target for antiviral drugs. A peptide corresponding to an optimal substrate has been modified at the C-terminus, by the addition of a warhead, to produce irreversible inhibitors that react as Michael acceptors with the enzyme active site. Further investigation highlighted key structural determinants for inhibition, with a positively charged P2 being particularly important for potency. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| France | 1 | 3% |
| Unknown | 28 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 33% |
| Student > Ph. D. Student | 5 | 17% |
| Professor | 3 | 10% |
| Student > Postgraduate | 2 | 7% |
| Student > Master | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 6 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 30% |
| Chemistry | 7 | 23% |
| Veterinary Science and Veterinary Medicine | 4 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 6 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2014.
All research outputs
#3,788,018
of 25,373,627 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#943
of 13,779 outputs
Outputs of similar age
#40,557
of 307,723 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#8
of 114 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,779 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.