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Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation

Overview of attention for article published in JCEM, May 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

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234 Dimensions

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225 Mendeley
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Title
Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation
Published in
JCEM, May 2017
DOI 10.1210/jc.2017-00672
Pubmed ID
Authors

Carlos Salomon, Dominic Guanzon, Katherin Scholz-Romero, Sherri Longo, Paula Correa, Sebastian E Illanes, Gregory E Rice

Abstract

There is a need to develop strategies for early prediction of patients who will develop preeclampsia (PE), in order to establish preventive strategies to reduce the prevalence and severity of the disease and their associated complications. The objective of this study was to investigate whether exosomes and their microRNA cargo present in maternal circulation can be used as early biomarker for PE. A retrospective stratified study design was used to quantify total exosomes (EXO) and placenta-derived exosomes (PdE) present in maternal plasma of normal (n=32 per time point) and PE (n=15 per time point) pregnancies. Exosomes present in maternal circulation were determined by Nanoparticle Tracking Analysis (NTA). An Illumina TrueSeq Small RNA kit was used to construct a small RNA library from exosomal RNA obtained from plasma samples. In presymptomatic women, who subsequently developed PE, the concentrations of EXO and PdE in maternal plasma were significantly greater than that those observed in controls, throughout pregnancy. The area under the ROC curves for EXO and PdE concentration were 0.745 ± 0.094 and 0.829 ± 0.077, respectively. In total, over 300 microRNAs were identified in exosomes across gestation, where hsa-miR-486-1-5p and hsa-miR-486-2-5p were identified as the candidate microRNAs. While the role of exosomes during PE remains to be fully elucidated, we suggest that the concentration and content of exosomes may be of diagnostic utility for women at risk of developing PE.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Unknown 224 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 20%
Researcher 30 13%
Student > Master 24 11%
Student > Bachelor 16 7%
Student > Doctoral Student 14 6%
Other 35 16%
Unknown 60 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 48 21%
Medicine and Dentistry 40 18%
Agricultural and Biological Sciences 14 6%
Immunology and Microbiology 9 4%
Engineering 9 4%
Other 28 12%
Unknown 77 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2022.
All research outputs
#2,202,903
of 25,382,440 outputs
Outputs from JCEM
#1,712
of 15,434 outputs
Outputs of similar age
#40,695
of 327,324 outputs
Outputs of similar age from JCEM
#16
of 95 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.