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Vagus Nerve Stimulation in children: A focus on intellectual disability

Overview of attention for article published in European Journal of Paediatric Neurology, January 2017
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Title
Vagus Nerve Stimulation in children: A focus on intellectual disability
Published in
European Journal of Paediatric Neurology, January 2017
DOI 10.1016/j.ejpn.2017.01.011
Pubmed ID
Authors

Jo Sourbron, Sylvia Klinkenberg, Alfons Kessels, Helenius Jurgen Schelhaas, Lieven Lagae, Marian Majoie

Abstract

Vagus Nerve Stimulation (VNS) can be an efficacious add-on treatment in patients with drug-resistant epilepsy, who are not eligible for surgery. Evidence of VNS efficacy in children with intellectual disability (ID) is scarce. The purpose of this study was to review all available VNS data in the pediatric population (≤18 years old) and focus on the subpopulation with ID since appropriate treatment of these children is often challenging and complex. Cochrane, EMBASE, PubMed and MEDLINE were used to collect all research associated to VNS and ID (or synonyms) leading to a total of 37 studies. Seven studies showed the results of patients with ID and those without separately; thereby only these studies were included in the VNS meta-analysis. Our meta-analysis showed that VNS was less effective in pediatric epilepsy patients with ID compared to those without ID (Mantel-Haenszel meta-analysis; p = 0.028, OR 0.18 (CI 95% 0.039-0.84)). However, there were no prospective controlled studies. Numerous studies reported quality of life (QoL) improvements in this subpopulation. The most common adverse events were transient and well tolerated. Side effects on cognition and behavior were not reported. These results might be a reason to consider VNS early on in the treatment of this subgroup. The significantly greater amount of retrospective studies, differences in follow-up (FU), lack of control data, heterogeneous series and limited number of patients could have biased the outcome measurements. Hence, current data do not exclude VNS for children with drug-resistant epilepsy and ID but should be interpreted with caution.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 81 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 12%
Student > Postgraduate 9 11%
Student > Master 9 11%
Student > Ph. D. Student 9 11%
Other 7 9%
Other 9 11%
Unknown 29 35%
Readers by discipline Count As %
Medicine and Dentistry 19 23%
Neuroscience 10 12%
Social Sciences 3 4%
Agricultural and Biological Sciences 2 2%
Nursing and Health Professions 2 2%
Other 11 13%
Unknown 35 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from European Journal of Paediatric Neurology
#778
of 1,112 outputs
Outputs of similar age
#322,167
of 424,069 outputs
Outputs of similar age from European Journal of Paediatric Neurology
#8
of 16 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,112 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.