Title |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
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Published in |
Nature Communications, May 2017
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DOI | 10.1038/ncomms15382 |
Pubmed ID | |
Authors |
Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J. Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M. Kang, David A. Hinds, Rajan P. Nair, Gonçalo R. Abecasis, James T Elder |
Abstract |
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including TH0, TH1 and TH17). The identified loci explain ∼28% of the genetic heritability and generate a discriminatory genetic risk score (AUC=0.76 in our sample) that is significantly correlated with age at onset (p=2 × 10(-89)). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 13% |
Switzerland | 1 | 13% |
United Kingdom | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 63% |
Scientists | 3 | 38% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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China | 1 | <1% |
Unknown | 262 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 14% |
Researcher | 35 | 13% |
Student > Bachelor | 32 | 12% |
Student > Master | 24 | 9% |
Other | 16 | 6% |
Other | 32 | 12% |
Unknown | 86 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 51 | 19% |
Biochemistry, Genetics and Molecular Biology | 43 | 16% |
Agricultural and Biological Sciences | 28 | 11% |
Immunology and Microbiology | 11 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
Other | 28 | 11% |
Unknown | 92 | 35% |