| Title |
The IL-1β phenomena in neuroinflammatory diseases
|
|---|---|
| Published in |
Journal of Neural Transmission, May 2017
|
| DOI | 10.1007/s00702-017-1732-9 |
| Pubmed ID | |
| Authors |
Andrew S. Mendiola, Astrid E. Cardona |
| Abstract |
It is becoming increasingly clear that neuroinflammation has a causal role in the pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic strategies targeting the regulation or availability of inflammatory mediators can be used to prevent or mitigate pathology. Interestingly, the proinflammatory cytokine, interleukin-1 beta (IL-1β), has been implicated in perpetuating immune responses and contributing to disease severity in a variety of CNS diseases ranging from multiple sclerosis, neurodegenerative diseases, traumatic brain injury, and diabetic retinopathy. Moreover, pharmacological blockade of IL-1 signaling has shown to be beneficial in some autoimmune and autoinflammatory diseases, making IL-1β a promising therapeutic target in neuroinflammatory conditions. This review highlights recent advances of our understanding on the multifaceted roles of IL-1β in neuroinflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 75% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 206 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 15% |
| Student > Master | 30 | 15% |
| Student > Bachelor | 28 | 14% |
| Researcher | 15 | 7% |
| Student > Doctoral Student | 9 | 4% |
| Other | 25 | 12% |
| Unknown | 68 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 36 | 17% |
| Medicine and Dentistry | 25 | 12% |
| Biochemistry, Genetics and Molecular Biology | 22 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
| Immunology and Microbiology | 9 | 4% |
| Other | 23 | 11% |
| Unknown | 81 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2023.
All research outputs
#4,270,918
of 23,989,683 outputs
Outputs from Journal of Neural Transmission
#344
of 1,846 outputs
Outputs of similar age
#71,882
of 316,819 outputs
Outputs of similar age from Journal of Neural Transmission
#11
of 26 outputs
Altmetric has tracked 23,989,683 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,846 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.