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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular Nanoshearing: An Innovative Approach to Shear off Molecules with AC-Induced Nanoscopic Fluid Flow
|
|---|---|
| Published in |
Scientific Reports, January 2014
|
| DOI | 10.1038/srep03716 |
| Pubmed ID | |
| Authors |
Muhammad J. A. Shiddiky, Ramanathan Vaidyanathan, Sakandar Rauf, Zhikai Tay, Matt Trau |
| Abstract |
Early diagnosis of disease requires highly specific measurement of molecular biomarkers from femto to pico-molar concentrations in complex biological (e.g., serum, blood, etc.) samples to provide clinically useful information. While reaching this detection limit is challenging in itself, these samples contain numerous other non-target molecules, most of which have a tendency to adhere to solid surfaces via nonspecific interactions. Herein, we present an entirely new methodology to physically displace nonspecifically bound molecules from solid surfaces by utilizing a newly discovered "tuneable force", induced by an applied alternating electric field, which occurs within few nanometers of an electrode surface. This methodology thus offers a unique ability to shear-off loosely bound molecules from the solid/liquid interface. Via this approach, we achieved a 5-fold reduction in nonspecific adsorption of non-target protein molecules and a 1000-fold enhancement for the specific capture of HER2 protein in human serum. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 29% |
| Student > Master | 6 | 15% |
| Other | 5 | 12% |
| Researcher | 5 | 12% |
| Student > Bachelor | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 11 | 27% |
| Chemistry | 10 | 24% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Agricultural and Biological Sciences | 2 | 5% |
| Medicine and Dentistry | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 7 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2014.
All research outputs
#17,709,056
of 22,739,983 outputs
Outputs from Scientific Reports
#86,471
of 122,590 outputs
Outputs of similar age
#219,101
of 304,414 outputs
Outputs of similar age from Scientific Reports
#442
of 706 outputs
Altmetric has tracked 22,739,983 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 122,590 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,414 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 706 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.