| Title |
Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells
|
|---|---|
| Published in |
JBIC Journal of Biological Inorganic Chemistry, May 2017
|
| DOI | 10.1007/s00775-017-1467-y |
| Pubmed ID | |
| Authors |
Mia C. Akerfeldt, Carmen M.-N. Tran, Clara Shen, Trevor W. Hambley, Elizabeth J. New |
| Abstract |
There is much interest in understanding the mechanisms by which platinum-based anticancer agents enter cells, and the copper transporter CTR1 has been the focus of many recent studies. While there is a clinical correlation between CTR1 levels and platinum efficacy, cellular studies have provided conflicting evidence relating to the relationship between cisplatin and CTR1. We report here our studies of the relationship between cisplatin and copper homeostasis in human colon cancer cells. While the accumulation of copper and platinum do not appear to compete with each other, we did observe that cisplatin perturbs CTR1 distribution within 10 min, a far shorter incubation time than commonly employed in cellular studies of cisplatin. Furthermore, on these short time-scales, cisplatin caused an increase in the cytoplasmic labile copper pool. While the predominant focus of studies to date has been on CTR1, these studies highlight the importance of investigating the interaction of cisplatin with other copper proteins. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 33% |
| Australia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 24% |
| Student > Bachelor | 7 | 21% |
| Student > Master | 6 | 18% |
| Researcher | 3 | 9% |
| Student > Doctoral Student | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 6 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 26% |
| Medicine and Dentistry | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 0 | 0% |
| Unknown | 9 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#14,902,124
of 23,842,189 outputs
Outputs from JBIC Journal of Biological Inorganic Chemistry
#438
of 664 outputs
Outputs of similar age
#177,442
of 315,408 outputs
Outputs of similar age from JBIC Journal of Biological Inorganic Chemistry
#3
of 8 outputs
Altmetric has tracked 23,842,189 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 664 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.