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The synaptic proteome in Alzheimer's disease

Overview of attention for article published in Alzheimer's & Dementia: the Journal of the Alzheimer's Association, November 2012
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Title
The synaptic proteome in Alzheimer's disease
Published in
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, November 2012
DOI 10.1016/j.jalz.2012.04.009
Pubmed ID
Authors

Rachel Yoon Kyung Chang, Amanda S. Nouwens, Peter R. Dodd, Naomi Etheridge

Abstract

Synaptic dysfunction occurs early in Alzheimer's disease (AD) and is recognized to be a primary pathological target for treatment. Synapse degeneration or dysfunction contributes to clinical signs of dementia through altered neuronal communication; the degree of synaptic loss correlates strongly with cognitive impairment. The molecular mechanisms underlying synaptic degeneration are still unclear, and identifying abnormally expressed synaptic proteins in AD brain will help to elucidate such mechanisms and to identify therapeutic targets that might slow AD progression.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 4%
United States 1 1%
Australia 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 23%
Researcher 14 18%
Student > Master 13 17%
Student > Doctoral Student 6 8%
Student > Bachelor 4 5%
Other 13 17%
Unknown 10 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 28%
Biochemistry, Genetics and Molecular Biology 11 14%
Neuroscience 9 12%
Computer Science 3 4%
Psychology 3 4%
Other 12 15%
Unknown 18 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#3,732
of 4,060 outputs
Outputs of similar age
#171,724
of 192,216 outputs
Outputs of similar age from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#45
of 52 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,216 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.