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Mendeley readers
Attention Score in Context
| Title |
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
|
|---|---|
| Published in |
Human Molecular Genetics, January 2014
|
| DOI | 10.1093/hmg/ddt675 |
| Pubmed ID | |
| Authors |
Alireza Moayyeri, Yi-Hsiang Hsu, David Karasik, Karol Estrada, Su-Mei Xiao, Carrie Nielson, Priya Srikanth, Sylvie Giroux, Scott G. Wilson, Hou-Feng Zheng, Albert V. Smith, Stephen R. Pye, Paul J. Leo, Alexander Teumer, Joo-Yeon Hwang, Claes Ohlsson, Fiona McGuigan, Ryan L. Minster, Caroline Hayward, José M. Olmos, Leo-Pekka Lyytikäinen, Joshua R. Lewis, Karin M.A. Swart, Laura Masi, Chris Oldmeadow, Elizabeth G. Holliday, Sulin Cheng, Natasja M. van Schoor, Nicholas C. Harvey, Marcin Kruk, Fabiola del Greco M, Wilmar Igl, Olivia Trummer, Efi Grigoriou, Robert Luben, Ching-Ti Liu, Yanhua Zhou, Ling Oei, Carolina Medina-Gomez, Joseph Zmuda, Greg Tranah, Suzanne J. Brown, Frances M. Williams, Nicole Soranzo, Johanna Jakobsdottir, Kristin Siggeirsdottir, Kate L. Holliday, Anke Hannemann, Min Jin Go, Melissa Garcia, Ozren Polasek, Marika Laaksonen, Kun Zhu, Anke W. Enneman, Mark McEvoy, Roseanne Peel, Pak Chung Sham, Maciej Jaworski, Åsa Johansson, Andrew A. Hicks, Pawel Pludowski, Rodney Scott, Rosalie A.M. Dhonukshe-Rutten, Nathalie van der Velde, Mika Kähönen, Jorma S. Viikari, Harri Sievänen, Olli T. Raitakari, Jesús González-Macías, Jose L. Hernández, Dan Mellström, Östen Ljunggren, Yoon Shin Cho, Uwe Völker, Matthias Nauck, Georg Homuth, Henry Völzke, Robin Haring, Matthew A. Brown, Eugene McCloskey, Geoffrey C. Nicholson, Richard Eastell, John A. Eisman, Graeme Jones, Ian R. Reid, Elaine M. Dennison, John Wark, Steven Boonen, Dirk Vanderschueren, Frederick C.W. Wu, Thor Aspelund, J. Brent Richards, Doug Bauer, Albert Hofman, Kay-Tee Khaw, George Dedoussis, Barbara Obermayer-Pietsch, Ulf Gyllensten, Peter P. Pramstaller, Roman S. Lorenc, Cyrus Cooper, Annie Wai Chee Kung, Paul Lips, Markku Alen, John Attia, Maria Luisa Brandi, Lisette C.P.G.M. de Groot, Terho Lehtimäki, José A. Riancho, Harry Campbell, Yongmei Liu, Tamara B. Harris, Kristina Akesson, Magnus Karlsson, Jong-Young Lee, Henri Wallaschofski, Emma L. Duncan, Terence W. O'Neill, Vilmundur Gudnason, Timothy D. Spector, François Rousseau, Eric Orwoll, Steven R. Cummings, Nick J. Wareham, Fernando Rivadeneira, Andre G. Uitterlinden, Richard L. Prince, Douglas P. Kiel, Jonathan Reeve, Stephen K. Kaptoge |
| Abstract |
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology. |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Iceland | 1 | <1% |
| Unknown | 116 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 17% |
| Researcher | 18 | 15% |
| Professor | 16 | 14% |
| Professor > Associate Professor | 10 | 8% |
| Student > Doctoral Student | 9 | 8% |
| Other | 28 | 24% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 36% |
| Biochemistry, Genetics and Molecular Biology | 13 | 11% |
| Agricultural and Biological Sciences | 10 | 8% |
| Nursing and Health Professions | 4 | 3% |
| Social Sciences | 3 | 3% |
| Other | 15 | 13% |
| Unknown | 31 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Human Molecular Genetics
#7,915
of 8,251 outputs
Outputs of similar age
#281,853
of 321,184 outputs
Outputs of similar age from Human Molecular Genetics
#94
of 97 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.